急性肾损伤治疗的神经免疫调节：从实验到临床的见解。

IF 3.5 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology Pub Date : 2025-10-08 DOI:10.1016/j.semnephrol.2025.151674

William T Nash, Mark D Okusa

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引用次数: 0

摘要

在过去的25年里，神经免疫调节已经成为预防和治疗急性肾损伤的一种引人注目的方法。通过胆碱能抗炎途径刺激迷走神经可以抑制炎症反应，并在动物疾病模型和多种人类炎症条件下显示出治疗潜力。这种神经免疫调节保护的机制是复杂的，但自2000年以来开展的研究大大提高了我们对所涉及的关键因素的理解。这项研究也产生了有趣的结果和意想不到的观察结果。在这篇综述中，我们强调了目前对迷走神经介导的神经免疫调节的见解，不确定的领域，以及AKI治疗调节的有希望的方向。Semin Nephrol 36:x-xx©20XX Elsevier Inc.。版权所有。

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Neuroimmune Regulation for Acute Kidney Injury Therapy: Insights Along the Path From Bench to Bedside.

Over the past 25 years, neuroimmune regulation has emerged as a compelling approach to the prevention and treatment of acute kidney injury. Vagus nerve stimulation through the cholinergic anti-inflammatory pathway can suppress inflammatory responses and demonstrate therapeutic potential in both animal disease models and a variety of human inflammatory conditions. The mechanisms underlying this neuroimmune-regulated protection are complex, but research undertaken since 2000 has significantly advanced our understanding of the key elements involved. This research has also yielded intriguing results and unexpected observations. In this review, we highlight current insights into vagus nerve-mediated neuroimmune regulation, areas of ongoing uncertainty, and promising directions for therapeutic modulation in AKI. Semin Nephrol 36:x-xx © 20XX Elsevier Inc. All rights reserved.

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来源期刊

Seminars in nephrology 医学-泌尿学与肾脏学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Nephrology is a timely source for the publication of new concepts and research findings relevant to the clinical practice of nephrology. Each issue is an organized compendium of practical information that serves as a lasting reference for nephrologists, internists and physicians in training.