二甲双胍：治疗多效性的范例（1922-2025）。

IF 2.1 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Medicina Clinica Pub Date : 2025-10-08 DOI:10.1016/j.medcli.2025.107189

Alberto de Leiva Hidalgo , Ferran Morell Brotad

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引用次数: 0

摘要

维尔纳和贝尔在1922年合成了二甲双胍。2006年，国际糖尿病联合会认定二甲双胍为治疗2型糖尿病的一线药物。本文综述了二甲双胍在治疗糖尿病、妊娠糖尿病、多囊卵巢综合征、食欲调节、肠道菌群失调、心血管和肾脏保护、特发性肺纤维化、降低各种肿瘤的风险和死亡率、延长寿命等方面的药理作用、不良反应和治疗多效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Metformina: paradigma de pleiotropismo terapéutico (1922-2025)

Werner and Bell synthesized metformin in 1922. In 2006, the International Diabetes Federation recognized metformin as the first-line drug for the treatment of type 2 diabetes. This review updates the pharmacological properties, adverse effects and therapeutic pleiotropism of metformin applied to the treatment of diabetes mellitus, gestational diabetes, polycystic ovary syndrome, appetite regulation, intestinal flora dysbiosis, cardiovascular and renal protection, treatment of idiopathic pulmonary fibrosis, reduction of risk and mortality from various neoplasms, and prolongation of lifespan.

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来源期刊

Medicina Clinica 医学-医学：内科

CiteScore

3.10

自引率

5.10%

发文量

295

审稿时长

22 days

期刊介绍： Medicina Clínica, fundada en 1943, es una publicación quincenal dedicada a la promoción de la investigación y de la práctica clínica entre los especialistas de la medicina interna, así como otras especialidades. Son características fundamentales de esta publicación el rigor científico y metodológico de sus artículos, la actualidad de los temas y, sobre todo, su sentido práctico, buscando siempre que la información sea de la mayor utilidad en la práctica clínica.