胃肠道与年龄相关的变化

IF 38.6 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Lancet Gastroenterology & Hepatology Pub Date : 2025-10-08 DOI:10.1016/s2468-1253(25)00235-3

Alberto Pilotto, Carlo Custodero, Lucilla Crudele, Wanda Morganti, Nicola Veronese, Marilisa Franceschi

{"title":"胃肠道与年龄相关的变化","authors":"Alberto Pilotto, Carlo Custodero, Lucilla Crudele, Wanda Morganti, Nicola Veronese, Marilisa Franceschi","doi":"10.1016/s2468-1253(25)00235-3","DOIUrl":null,"url":null,"abstract":"Disorders of the gastrointestinal tract are common in those aged 65 years or older, impairing their quality of life and potentially increasing morbidity and mortality risk. Unlike many organ systems, the luminal gastrointestinal tract does not undergo much natural degeneration. However, age-related anatomical and functional changes of the gastrointestinal tract might promote pathophysiology and explain some atypical presentations of gastrointestinal disorders in older adults. This Review summarises current knowledge of major anatomical and functional changes that occur in the gastrointestinal tract during ageing. These changes are often more evident in older adults who are frail or multimorbid, and frailty in older age might also influence the presentation, prognosis, and management of older patients with gastrointestinal disorders.","PeriodicalId":56028,"journal":{"name":"Lancet Gastroenterology & Hepatology","volume":"116 1","pages":""},"PeriodicalIF":38.6000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Age-related changes of the gastrointestinal tract\",\"authors\":\"Alberto Pilotto, Carlo Custodero, Lucilla Crudele, Wanda Morganti, Nicola Veronese, Marilisa Franceschi\",\"doi\":\"10.1016/s2468-1253(25)00235-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Disorders of the gastrointestinal tract are common in those aged 65 years or older, impairing their quality of life and potentially increasing morbidity and mortality risk. Unlike many organ systems, the luminal gastrointestinal tract does not undergo much natural degeneration. However, age-related anatomical and functional changes of the gastrointestinal tract might promote pathophysiology and explain some atypical presentations of gastrointestinal disorders in older adults. This Review summarises current knowledge of major anatomical and functional changes that occur in the gastrointestinal tract during ageing. These changes are often more evident in older adults who are frail or multimorbid, and frailty in older age might also influence the presentation, prognosis, and management of older patients with gastrointestinal disorders.\",\"PeriodicalId\":56028,\"journal\":{\"name\":\"Lancet Gastroenterology & Hepatology\",\"volume\":\"116 1\",\"pages\":\"\"},\"PeriodicalIF\":38.6000,\"publicationDate\":\"2025-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lancet Gastroenterology & Hepatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/s2468-1253(25)00235-3\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lancet Gastroenterology & Hepatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/s2468-1253(25)00235-3","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

胃肠道疾病在65岁或以上的老年人中很常见，损害了他们的生活质量，并潜在地增加了发病率和死亡率的风险。与许多器官系统不同，胃肠道不会经历太多的自然退化。然而，与年龄相关的胃肠道解剖和功能改变可能促进病理生理，并解释了老年人胃肠道疾病的一些非典型表现。这篇综述总结了目前关于胃肠道在衰老过程中发生的主要解剖和功能变化的知识。这些变化通常在体弱多病的老年人中更为明显，老年人的体弱多病也可能影响老年胃肠道疾病患者的表现、预后和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Age-related changes of the gastrointestinal tract

Disorders of the gastrointestinal tract are common in those aged 65 years or older, impairing their quality of life and potentially increasing morbidity and mortality risk. Unlike many organ systems, the luminal gastrointestinal tract does not undergo much natural degeneration. However, age-related anatomical and functional changes of the gastrointestinal tract might promote pathophysiology and explain some atypical presentations of gastrointestinal disorders in older adults. This Review summarises current knowledge of major anatomical and functional changes that occur in the gastrointestinal tract during ageing. These changes are often more evident in older adults who are frail or multimorbid, and frailty in older age might also influence the presentation, prognosis, and management of older patients with gastrointestinal disorders.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Lancet Gastroenterology & Hepatology Medicine-Hepatology

CiteScore

50.30

自引率

1.10%

发文量

期刊介绍： The Lancet Gastroenterology & Hepatology is an authoritative forum for key opinion leaders across medicine, government, and health systems to influence clinical practice, explore global policy, and inform constructive, positive change worldwide. The Lancet Gastroenterology & Hepatology publishes papers that reflect the rich variety of ongoing clinical research in these fields, especially in the areas of inflammatory bowel diseases, NAFLD and NASH, functional gastrointestinal disorders, digestive cancers, and viral hepatitis.