乙烯基异氰酸酯与二芳基二硫化物/1,2 -二烷基二烷的可见光诱导环化合成1 -取代异喹啉

IF 2.7 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-10-09 DOI:10.1002/ejoc.202500715

Yong‐Xin Liang, Qing‐Wen Ai, Xue‐Cen Xu, Yu‐Long Zhao

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引用次数: 0

摘要

异喹啉类化合物，尤其是1 -取代衍生物，由于其在天然产物和药物中的普遍存在而引起了相当大的关注。本文提出了一种新的可见光诱导的乙烯基异氰酸酯与二硫化物或1,2 -二烷基二烷的串联环化反应。该反应可耐受多种底物，并为从易于获得的原料中一步合成1 -硫代/硒代异喹啉提供了一种环保的途径。

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Visible‐Light‐Induced Cyclization of Vinyl Isocyanides with Diaryl Disulfides/1,2‐Dialkyldiselanes for the Synthesis of 1‐Substituted Isoquinolines

Isoquinoline compounds, especially 1‐substituted derivatives, have garnered considerable attention due to their ubiquitous presence in natural products and pharmaceuticals. Herein, a novel visible‐light‐induced tandem cyclization of vinyl isocyanides with diaryl disulfides or 1,2‐dialkyldiselanes has been developed. The reaction tolerates a wide range of substrates and provides an environmentally friendly route to the synthesis of 1‐thio/selenoisoquinolines from the easily available starting materials in a single step.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.