{"title":"低剂量口服西马鲁肽治疗肥胖…还有其他研究","authors":"Tom Nolan","doi":"10.1136/bmj.r2050","DOIUrl":null,"url":null,"abstract":"Tom Nolan reviews this week’s research Multicancer detection (MCD) tests are available to buy—although may set you back more than a thousand pounds. Websites offering the tests, that usually detect fragments of DNA released by cancer cells, seem to imply an established evidence base for them, such as that they’ve been validated on over 40 000 participants. A systematic review suggests there is still a way to go: the authors searched for controlled studies in screening populations and found no controlled studies that report benefits of screening with MCD tests. The NHS-Galleri trial should change that and is expected to report its findings next year. Ann Intern Med doi:10.7326/ANNALS-25-01877 Countless headlines exalt the life changing benefits of newer …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"33 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Low dose oral semaglutide for obesity . . . and other research\",\"authors\":\"Tom Nolan\",\"doi\":\"10.1136/bmj.r2050\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Tom Nolan reviews this week’s research Multicancer detection (MCD) tests are available to buy—although may set you back more than a thousand pounds. Websites offering the tests, that usually detect fragments of DNA released by cancer cells, seem to imply an established evidence base for them, such as that they’ve been validated on over 40 000 participants. A systematic review suggests there is still a way to go: the authors searched for controlled studies in screening populations and found no controlled studies that report benefits of screening with MCD tests. The NHS-Galleri trial should change that and is expected to report its findings next year. Ann Intern Med doi:10.7326/ANNALS-25-01877 Countless headlines exalt the life changing benefits of newer …\",\"PeriodicalId\":22388,\"journal\":{\"name\":\"The BMJ\",\"volume\":\"33 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The BMJ\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1136/bmj.r2050\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The BMJ","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/bmj.r2050","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
汤姆·诺兰（Tom Nolan）评论了本周的研究报告：多种癌症检测（MCD）测试是可以买到的——尽管可能要花你一千多英镑。提供这些测试的网站通常检测癌细胞释放的DNA片段，似乎意味着它们有一个既定的证据基础，比如它们已经在4万多名参与者身上得到了验证。一项系统评价表明，仍有一段路要走：作者搜索了筛查人群的对照研究，发现没有对照研究报告MCD检测筛查的好处。NHS-Galleri试验应该会改变这种情况，并有望在明年报告其结果。Ann Intern Med doi:10.7326/ANNALS-25-01877无数的头条新闻赞扬了更新…
Low dose oral semaglutide for obesity . . . and other research
Tom Nolan reviews this week’s research Multicancer detection (MCD) tests are available to buy—although may set you back more than a thousand pounds. Websites offering the tests, that usually detect fragments of DNA released by cancer cells, seem to imply an established evidence base for them, such as that they’ve been validated on over 40 000 participants. A systematic review suggests there is still a way to go: the authors searched for controlled studies in screening populations and found no controlled studies that report benefits of screening with MCD tests. The NHS-Galleri trial should change that and is expected to report its findings next year. Ann Intern Med doi:10.7326/ANNALS-25-01877 Countless headlines exalt the life changing benefits of newer …
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