伴有ALK融合的smarca4缺失非小细胞肺癌1例

IF 1.2

Applied immunohistochemistry & molecular morphology : AIMM Pub Date : 2025-10-06 DOI:10.1097/PAI.0000000000001289

Anne-Laure Désage, Simon Pointel, Eric Ezingeard, Sophie Bayle-Bleuez, Daniel Pissaloux, Fabien Forest

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引用次数: 0

摘要

缺乏smarca4的非小细胞肺癌通常预后较差，并与吸烟相关的突变有关。在这里，我们报告了一例发生在非吸烟女性的smarca4缺陷非小细胞肺癌（NSCLC），并伴有ALK融合。我们的病例提醒医生，对于发生在非吸烟者的smarca4缺陷非小细胞肺癌的分子生物学结果要特别谨慎。

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SMARCA4-deficient Non-small Cell Lung Carcinoma Harboring ALK Fusion: A Case Report.

SMARCA4-deficient non-small cell lung cancers are usually of poor prognosis and associated with smoking-related mutations. Here, we report the case of a SMARCA4-deficient non-small cell lung cancer (NSCLC) occurring in a non-smoker female and harboring ALK fusion. Our case highlights for physicians to be especially cautious with molecular biological results in case of SMARCA4-deficient non-small cell lung cancer occurring in nonsmokers.

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Applied immunohistochemistry & molecular morphology : AIMM

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