n6 -甲基腺苷（m6A）在血管平滑肌疾病中的修饰

IF 2.3 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of Vascular Research Pub Date : 2025-10-07 DOI:10.1159/000548372

Chengjun Huang, Xianping Long, Ranzun Zhao

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引用次数: 0

摘要

血管平滑肌细胞（VSMCs）的损伤会引起许多血管疾病，如动脉粥样硬化、高血压和心脏病。研究表明，n6 -甲基腺苷（m6A）修饰可调节血管环境下VSMCs的功能。m6A修饰通过调节RNA代谢，影响VSMCs的增殖、迁移、表型转化和凋亡等关键生物学过程。我们旨在研究m6A修饰及其相关酶在VSMC功能障碍引起的血管疾病中的作用，并探索其作为治疗靶点的潜力，从而科学地开发针对VSMC功能障碍的药物。

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N6-methyladenosine (m6A) modification in Vascular Smooth Muscle Disease: A Review.

: The impairment of vascular smooth muscle cells (VSMCs) causes many vascular diseases, such as atherosclerosis, hypertension, and heart conditions. Research has shown that N6-methyladenosine (m6A) modification regulates s VSMCs ' function in a vascular environment. By regulating RNA metabolism, m6A modification affects key biological processes in VSMCs, such as proliferation, migration, phenotypic transformation, and apoptosis. We aim to examine the role of m6A modification and its associated enzymes in vascular diseases caused by VSMC dysfunction, and explore its potential as a therapeutic target, so that we can develop drugs targeting VSMC dysfunction on a scientific basis.

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来源期刊

Journal of Vascular Research 医学-生理学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The ''Journal of Vascular Research'' publishes original articles and reviews of scientific excellence in vascular and microvascular biology, physiology and pathophysiology. The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation. JVR''s ''Vascular Update'' series regularly presents state-of-the-art reviews on hot topics in vascular biology. Manuscript processing times are, consistent with stringent review, kept as short as possible due to electronic submission. All articles are published online first, ensuring rapid publication. The ''Journal of Vascular Research'' is the official journal of the European Society for Microcirculation. A biennial prize is awarded to the authors of the best paper published in the journal over the previous two years, thus encouraging young scientists working in the exciting field of vascular biology to publish their findings.