对抗逆转录病毒治疗完全有效的肛门浆母细胞淋巴瘤1例报告。

IF 0.6 4区医学 Q4 SURGERY

South African Journal of Surgery Pub Date : 2025-06-01 DOI:10.36303/SAJS.00917

D Montwedi, M Ramabulana, N Khan

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引用次数: 0

摘要

摘要：一名40岁男性，已知人类免疫缺陷病毒（HIV）阳性，表现为肛门周围大肿块和粪便阻塞。他的CD4计数为121个细胞/mm3，表明他患有晚期艾滋病毒，并开始接受二线抗逆转录病毒治疗。磁共振成像（MRI）证实一个大肿块累及肛门直肠交界处。肿瘤活检显示为浆母细胞淋巴瘤（PBL）。为治疗大便阻塞，行转移结肠造口术。在等待化疗期间，肿瘤迅速缩小，临床完全消退。PBL罕见，预后不佳。PBL的自发消退已有报道，但二线抗逆转录药物治疗后的消退尚未见报道。

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Anal plasmablastic lymphoma with complete response to antiretroviral therapy - a case report.

Summary: A 40-year-old male, known to be positive with the human immunodeficiency virus (HIV), presented with a large perianal mass and faecal obstruction. His CD4 count was 121 cells/mm3 suggesting advanced HIV disease, and he was started on second-line antiretroviral therapy. Magnetic resonance imaging (MRI) confirmed a large mass involving the anorectal junction. A biopsy of the tumor revealed a plasmablastic lymphoma (PBL). A diverting colostomy was performed for faecal obstruction. While awaiting chemotherapy treatment, the tumour rapidly decreased in size with complete clinical resolution. PBL is rare and has a dismal prognosis. Spontaneous regression of PBL has been reported but regression on second-line antiretroval therapy has not been previously described.

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来源期刊

South African Journal of Surgery 医学-外科

CiteScore

0.80

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： The South African Journal of Surgery (SAJS) is a quarterly, general surgical journal. It carries research articles and letters, editorials, clinical practice and other surgical articles and personal opinion, South African health-related news, obituaries and general correspondence.