辛伐他汀粉末和辛伐他汀凝胶第三磨牙骨再生的比较评价-裂口研究。

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE
Journal of Maxillofacial & Oral Surgery Pub Date : 2025-10-01 Epub Date: 2025-03-13 DOI:10.1007/s12663-025-02497-1
Sanika Tidke, Pushkar P Waknis, Ravidra Badhe, Kalyani Bhate, Sneha Setiya, Samkit Sakhariya
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引用次数: 0

摘要

目的:评价和比较辛伐他汀粉末和辛伐他汀凝胶在第三磨牙拔牙后的骨再生效果。材料和方法:随机、裂口、单盲、单中心试验对10例需要手术拔除双侧阻生下颌第三磨牙的患者进行了研究。每个参与者被随机分配在一个孔中接受用药物辛伐他汀(10mg)浸泡的明胶泡沫,在另一个孔中接受辛伐他汀凝胶。分别于第1、4、8、12周后用直方图分析灰度平均值,测定骨再生情况。在第1天和第7天,分别使用VAS评分和Landry等人评分来测量疼痛和伤口愈合。结果:两组比较采用配对t检验;两组的个体平均值均显示出显著的结果,最大平均值出现在第12周,表明辛伐他汀的使用有助于骨再生。结论:辛伐他汀有助于骨再生,建议在第三磨牙手术后使用辛伐他汀。尽管辛伐他汀凝胶具有成本效益,但在使用前必须新鲜制备。辛伐他汀的缓释应进一步研究使用不同的载体方法,将证明是有益的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Evaluation of Bone Regeneration in Third Molar Extraction Using Simvastatin Powder And Simvastatin Gel-A Split-Mouth Study.

Aim: To evaluate and compare bone regeneration in third molar extraction using simvastatin powder and simvastatin gel.

Materials and methods: A randomized, split-mouth, single-blinded, single-center trial was performed in 10 patients requiring surgical extraction of bilaterally impacted mandibular third molars. Each participant was randomly assigned to receive Gelfoam soaked with drug simvastatin (10 mg) in one socket and simvastatin gel in other socket. RVG was taken after the first, fourth, eighth, and twelfth weeks after analyzing the gray mean scale value with a histogram to determine bone regeneration. On Day 1 and Day 7, pain and wound healing were measured using the VAS scale and the Landry et al. scale, respectively.

Result: The paired t test was used to compare the two groups; individual means for both groups revealed a significant result, with the greatest mean appearing at the 12th week, suggesting that simvastatin usage aids bone regeneration.

Conclusion: We recommend using simvastatin after every third molar operation since it aids in bone regeneration. Even though simvastatin gel is cost effective, it must be prepared fresh before use. Sustained release of simvastatin should be further investigated using different carrier methods that would prove to be beneficial.

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来源期刊
Journal of Maxillofacial & Oral Surgery
Journal of Maxillofacial & Oral Surgery DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
1.90
自引率
0.00%
发文量
138
期刊介绍: This journal offers comprehensive coverage of new techniques, important developments and innovative ideas in Oral and Maxillofacial Surgery. Practice-applicable articles help develop the methods used to handle dentoalveolar surgery, facial injuries and deformities, TMJ disorders, oral cancer, jaw reconstruction, anesthesia and analgesia. The journal also includes specifics on new instruments, diagnostic equipment’s and modern therapeutic drugs and devices. Journal of Oral and Maxillofacial Surgery is recommended for first or priority subscription by the Dental Section of the Medical Library Association. Specific topics covered recently have included: ? distraction osteogenesis ? synthetic bone substitutes ? fibroblast growth factors ? fetal wound healing ? skull base surgery ? computer-assisted surgery ? vascularized bone grafts Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.
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