胆碱能基底前脑及其在神经变性中的作用。

IF 3 3区 医学 Q2 CLINICAL NEUROLOGY
Matthew D Cykowski, Joseph C Masdeu
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引用次数: 0

摘要

本文综述了胆碱能(Ch)基底前脑及其在神经变性中的作用。本文回顾了用于描述Ch细胞和基底前脑复杂区域的术语。实际解剖取样和标记策略的Ch细胞进行了讨论和说明,以促进诊断工作和解剖为基础的研究这一区域的目标。该系统的解剖连通性进行了审查,重点放在密集的胆碱能输入杏仁核,主要目标的基底前脑,以及海马。然后简要讨论了各种神经退行性疾病中的Ch和基底前脑神经病理学,包括最近对TDP-43蛋白病变的研究。最后,强调了可能进一步了解神经退行性变中Ch系统的进一步研究领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The cholinergic basal forebrain and its role in neurodegeneration.

This review examines the cholinergic (Ch) basal forebrain and its role in neurodegeneration. Terminology used to describe Ch cells and the complex region of the basal forebrain are reviewed. Practical autopsy sampling and labeling strategies for Ch cells are discussed and illustrated with the goal of facilitating diagnostic work and autopsy-based studies of this region. The anatomic connectivity of the system is reviewed with an emphasis placed on the dense cholinergic input to the amygdala, the major target of the Ch basal forebrain, as well as the hippocampus. Ch and basal forebrain neuropathology in various neurodegenerative diseases is then briefly discussed, including more recent studies of TDP-43 proteinopathies. Finally, areas for further study that might further the understanding of the Ch system in neurodegeneration are emphasized.

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来源期刊
CiteScore
5.40
自引率
6.20%
发文量
118
审稿时长
6-12 weeks
期刊介绍: Journal of Neuropathology & Experimental Neurology is the official journal of the American Association of Neuropathologists, Inc. (AANP). The journal publishes peer-reviewed studies on neuropathology and experimental neuroscience, book reviews, letters, and Association news, covering a broad spectrum of fields in basic neuroscience with an emphasis on human neurological diseases. It is written by and for neuropathologists, neurologists, neurosurgeons, pathologists, psychiatrists, and basic neuroscientists from around the world. Publication has been continuous since 1942.
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