PTT-119在人体内的药代动力学。

Chemioterapia : international journal of the Mediterranean Society of Chemotherapy Pub Date : 1988-04-01

F Pannuti, G Coppi, F Borella, A Martoni, L Urbano, B Melotti

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引用次数: 0

摘要

本文研究了新型烷基化剂PTT-119在8例晚期肿瘤患者体内的药代动力学。PTT-119以3mg /kg的剂量静脉注射后迅速从血浆中消失。HPLC法显示血浆中PPT-119主要代谢物m-双(二氯乙基)氨基苯基- l-丙氨酸的水平。血浆中药物的消除可以用单室模型来描述。半衰期平均值为77.8 min，总血浆清除率平均值为510.8 ml/min，分布容积平均值为0.69 l/kg。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pharmacokinetics of PTT-119 in man.

The pharmacokinetics of PTT-119, a new alkylating agent, was studied in 8 advanced cancer patients. PTT-119 disappeared rapidly from plasma after administration at a dose of 3 mg/kg by i.v. bolus injection. The HPLC method shows plasma levels of m-bis (dichloroethyl)amino-phenyl-L-alanine which is the major metabolite of PPT-119. Elimination of the drug from plasma can be described by a one-compartment model. Mean values of 77.8 min for the half-life, 510.8 ml/min for the total plasma clearance and 0.69 l/kg for the volume of distribution were found.

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Chemioterapia : international journal of the Mediterranean Society of Chemotherapy

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