具有供体-受体结构的有机铂桥接共轭聚合物光敏剂，用于增强光动力效率和综合肿瘤治疗

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-10-03 DOI:10.1039/d5cc05313g

Ziyin Tian, Gang Wen, Yuxin Yi, Xiling Mao, Shenglong Liao, Shouchun Yin

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引用次数: 0

摘要

研制了一种具有有机铂桥联二聚芴结构的共轭聚合物P1，用于光动力、光热和化学化学的协同作用。P1纳米颗粒表现出强的近红外吸收，增强的活性氧（ROS）生成和高光热转换，在近红外照射下显示出优越的抗肿瘤功效。这项工作强调了具有内置化疗模块的共轭聚合物光敏剂杂交体作为组合肿瘤治疗的新范例的巨大潜力。

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Organoplatinum-bridged conjugated polymeric photosensitizer with donor-acceptor structure for enhanced photodynamic efficiency and integrated tumour therapy

A conjugated polymer P1 with organoplatinum-bridged BODIPYfluorene structure is developed for synergistic photodynamic, photothermal and chemotherapy. P1 nanoparticles exhibit strong NIR absorption, enhanced reactive oxygen species (ROS) generation and high photothermal conversion, demonstrating superior antitumour efficacy under NIR irradiation. This work highlights the great potential of conjugated polymerphotosensitizer hybrids with built-in chemotherapeutic modules as a new paradigm for combinatorial tumour treatment.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.