骨保护素通过mTORC1调节肝脏葡萄糖代谢的新功能。

Diabetes Pub Date : 2025-09-30 DOI:10.2337/db25-0207

Sheng Qiu, Xia Wang, Ke Li, Siliang Zhang, Yerui Lai, Qiao Mi, Min Yang, Dongfang Liu, Ling Li, Qinan Wu, Mengliu Yang

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引用次数: 0

摘要

Opg启动子甲基化抑制肥胖小鼠肝脏Opg表达。肝脏OPG调节肥胖小鼠的葡萄糖代谢和胰岛素敏感性。OPG通过与哺乳动物雷帕霉素靶蛋白复合物1 （Raptor）相互作用调节葡萄糖代谢。小鼠Opg缺乏可减少与年龄相关的代谢功能障碍。

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Novel Function of Osteoprotegerin in the Modulation of Glucose Metabolism in the Liver via mTORC1.

Article highlights: Methylation of the Opg promoter inhibits hepatic OPG expression in obese mice. Hepatic OPG regulates glucose metabolism and insulin sensitivity in obese mice. OPG regulates glucose metabolism through interaction with mammalian target of rapamycin complex 1 (Raptor). Opg deficiency in mice reduces age-related metabolic dysfunction.

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来源期刊

Diabetes

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