3D-TSE成像对单纯SRS治疗脑转移患者的重要性。

IF 5.3 1区医学 Q1 ONCOLOGY

Radiotherapy and Oncology Pub Date : 2025-09-28 DOI:10.1016/j.radonc.2025.111172

Eyub Y. Akdemir , Joseph DiStefano , Kevin J. Abrams , Charif Sidani , Margaret C. Chaneles , Matthew D. Hall , Robert H. Press , D Jay Wieczorek , Ranjini Tolakanahalli , Alonso N. Gutierrez , Michael W. McDermott , Yazmin Odia , Minesh P. Mehta , Rupesh Kotecha

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引用次数: 0

摘要

本研究评估了3D涡轮自旋回波（3D- tse）成像在脑转移的立体定向放射外科（SRS）计划中的临床应用，探讨了将3D- tse添加到MPRAGE的价值。Dual-sequence MRI (MPRAGE + 3 d-tse)明显延长时间遥远的颅内失败(DIF)全脑放疗(WBRT)天真的病人(n = 308,11.4与6.8 月,p = 0.03),但不是以前的病人接受WBRT和打捞与SRS (n = 39岁,6.5与5.6 月,p = 0.76)。3D-TSE成像在WBRT-naïve组（19.6 %）的额外病变检测高于wbrt后患者（12.0 %）

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Importance of 3D-TSE imaging for patients with brain metastasis treated with SRS alone

This study evaluates the clinical utility of 3D turbo spin echo (3D-TSE) imaging in stereotactic radiosurgery (SRS) planning for brain metastases, examining the value of adding 3D-TSE to MPRAGE. Dual-sequence MRI (MPRAGE + 3D-TSE) significantly prolonged time to distant intracranial failure (DIF) in whole brain radiotherapy (WBRT)-naïve patients (n = 308, 11.4 vs. 6.8 months, p = 0.03), but not in patients previously treated with WBRT and salvaged with SRS (n = 39, 6.5 vs. 5.6 months, p = 0.76). Additional lesion detection attributed to 3D-TSE imaging was greater in WBRT-naïve (19.6 %) than in post-WBRT patients (12.0 %) (p < 0.001). The dual-sequence imaging may improve time to distant failure in the modern era for most patients treated with primary stereotactic radiosurgery and should be integrated into the SRS workflow.

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来源期刊

Radiotherapy and Oncology 医学-核医学

CiteScore

10.30

自引率

10.50%

发文量

2445

审稿时长

45 days

期刊介绍： Radiotherapy and Oncology publishes papers describing original research as well as review articles. It covers areas of interest relating to radiation oncology. This includes: clinical radiotherapy, combined modality treatment, translational studies, epidemiological outcomes, imaging, dosimetry, and radiation therapy planning, experimental work in radiobiology, chemobiology, hyperthermia and tumour biology, as well as data science in radiation oncology and physics aspects relevant to oncology.Papers on more general aspects of interest to the radiation oncologist including chemotherapy, surgery and immunology are also published.