Eyub Y Akdemir, Joseph DiStefano, Kevin J Abrams, Charif Sidani, Margaret C Chaneles, Matthew D Hall, Robert H Press, DJay Wieczorek, Ranjini Tolakanahalli, Alonso N Gutierrez, Michael W McDermott, Yazmin Odia, Minesh P Mehta, Rupesh Kotecha
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Importance of 3D-TSE imaging for patients with brain metastasis treated with SRS alone.
This study evaluates the clinical utility of 3D turbo spin echo (3D-TSE) imaging in stereotactic radiosurgery (SRS) planning for brain metastases, examining the value of adding 3D-TSE to MPRAGE. Dual-sequence MRI (MPRAGE + 3D-TSE) significantly prolonged time to distant intracranial failure (DIF) in whole brain radiotherapy (WBRT)-naïve patients (n = 308, 11.4 vs. 6.8 months, p = 0.03), but not in patients previously treated with WBRT and salvaged with SRS (n = 39, 6.5 vs. 5.6 months, p = 0.76). Additional lesion detection attributed to 3D-TSE imaging was greater in WBRT-naïve (19.6 %) than in post-WBRT patients (12.0 %) (p < 0.001). The dual-sequence imaging may improve time to distant failure in the modern era for most patients treated with primary stereotactic radiosurgery and should be integrated into the SRS workflow.
期刊介绍：
Radiotherapy and Oncology publishes papers describing original research as well as review articles. It covers areas of interest relating to radiation oncology. This includes: clinical radiotherapy, combined modality treatment, translational studies, epidemiological outcomes, imaging, dosimetry, and radiation therapy planning, experimental work in radiobiology, chemobiology, hyperthermia and tumour biology, as well as data science in radiation oncology and physics aspects relevant to oncology.Papers on more general aspects of interest to the radiation oncologist including chemotherapy, surgery and immunology are also published.
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