线粒体破坏在病毒介导的神经元损伤：一个机制的观点。

IF 4.6 3区医学 Q1 VIROLOGY

Journal of Medical Virology Pub Date : 2025-10-01 DOI:10.1002/jmv.70626

Shuqi Shi, Mingzhu Zhai, Benqing Wu, Wuping Sun

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引用次数: 0

摘要

神经损伤是病毒感染过程中不可忽视的重要病理问题。线粒体是细胞的能量工厂，在这种情况下发挥着独特的作用，当病毒感染宿主细胞时，线粒体受到严重影响。病毒通过特定的机制侵入和感染细胞，引起细胞结构和功能的改变。这些变化不仅直接影响线粒体，而且通过间接途径破坏线粒体的正常功能。本文综述了SARS-CoV-2、疱疹病毒、人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV）感染诱导线粒体损伤的机制，为预防和治疗神经元损伤提供新的见解和策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Mitochondrial Disruption in Viral-Mediated Neuronal Injury: A Mechanistic Perspective

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Mitochondrial Disruption in Viral-Mediated Neuronal Injury: A Mechanistic Perspective

Neuronal injury is a major pathological issue that cannot be ignored during viral infections. Mitochondria, the energy factories of the cell, play a unique role in this scenario and are severely impacted when viruses infect host cells. Viruses invade and infect cells via specific mechanisms, causing changes in cellular structure and function. These changes not only directly affect mitochondria but also disrupt their normal function through indirect pathways. This paper reviews the mechanisms of mitochondrial damage induced by infections with SARS-CoV-2, herpesviruses, human immunodeficiency virus (HIV), and hepatitis C virus (HCV), providing new insights and strategies for preventing and treating neuronal injury.

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来源期刊

Journal of Medical Virology 医学-病毒学

CiteScore

23.20

自引率

2.40%

发文量

777

审稿时长

1 months

期刊介绍： The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.