钯催化的烯系氨基甲酰氯与多氟芳烃的Heck/多氟芳基化。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-10-01 DOI:10.1039/d5cc04604a

Chen Chen, Zi-Yi Wang, Xin-Yu Hu, Xiao-Xu Zhang, Yan-Ping Zhu, Chunjie Ni, Bolin Zhu

引用次数: 0

摘要

我们开发了一种pd催化的Heck/多氟芳基级联反应，以烯烃系链氨基甲酰氯为原料合成具有全碳季中心的多氟芳基氧吲哚。将反应扩展到使用胺、BTC和多氟芳烃的三组分一锅方案，初步获得了不对称结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Palladium-catalyzed Heck/polyfluoroarylation of alkene-tethered carbamoyl chlorides with polyfluoroarenes.

We developed a Pd-catalyzed Heck/polyfluoroarylation cascade to synthesize polyfluoroarylated oxindoles with all-carbon quaternary centers from alkene-tethered carbamoyl chlorides. The reaction was extended to a three-component one-pot protocol using amines, BTC, and polyfluoroarenes, with preliminary asymmetric results achieved.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.