Abelardo Gutiérrez Hernández, Francisco J. Sierra-Molero, Alejandro Baeza Carratalá, Francisco Méndez, Claudia Araceli Contreras-Celedón and Diego A. Alonso
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Sustainable synthesis of sulfonamides via oxidative chlorination in alternative solvents: a general, mild, and eco-friendly strategy
A general, mild, and environmentally friendly method for synthesizing sulfonamides in sustainable solvents was developed. Sodium dichloroisocyanurate dihydrate (NaDCC·2H2O) served as an efficient oxidant for converting thiols to sulfonyl chlorides, which then reacted in situ with various amines to afford sulfonamides in good to excellent yields in water, EtOH, glycerol and the DES ChCl/glycerol: 1/2. The process features simple conditions and a solvent-free workup involving only filtration, highlighting its potential as a green and practical approach to sulfonamide synthesis.
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