2'-聚焦乳糖改善AD小鼠的认知障碍和神经炎症。

IF 6.2 1区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of Agricultural and Food Chemistry Pub Date : 2025-09-30 DOI:10.1021/acs.jafc.5c06137

Yumeng Ma,Ming Zhang,Yutong Jin,Yifei Wang,Tengteng Ji,Fang Wu,Yixuan Li,Ran Wang,Huiyuan Guo,Fazheng Ren,Bing Fang

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引用次数: 0

摘要

补充2′-焦酰基乳糖（2′- fl）有利于大脑功能。我们之前的研究已经报道了2′-FL对小鼠AD的预防作用；本研究评估了2′-FL在AD中的作用。5月龄雄性5 × FAD小鼠灌胃2'-FL 11周，2 mg 2'-FL显著改善认知缺陷，甚至恢复到正常水平。2′-FL可显著改善大鼠神经细胞的破坏、突触可塑性受损（以胆碱能神经元和谷氨酰胺能神经元减少为特征）以及小胶质细胞的活化。2′-FL还通过Keap1-Nrf2通路上调Nqo1表达，显著下调Il-6和Il-1β mRNA表达，减轻氧化损伤。ad增加了粪便和血清中PC（18:4/20:5）和DG(18:4/22:6/0:0)，均降低了2′-FL，与炎症呈显著正相关，与突触可塑性呈显著负相关。本研究为2′-FL在神经退行性疾病中的应用奠定了理论基础。

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2'-Fucosyllactose Ameliorates Cognitive Impairment and Neuroinflammation in AD Mice.

2'-Fucosyllactose (2'-FL) supplementation is beneficial to brain function. Our previous study has already reported the prevention of AD by 2'-FL in mice; in this study, the effects of 2'-FL in AD were evaluated. Five month-old male 5 × FAD mice were gavaged with 2'-FL for 11 weeks, and 2 mg of 2'-FL significantly improved cognitive deficits, even restoring them to the normal level. The destroyed neurons, damaged synaptic plasticity characterized by decreased cholinergic neurons and glutaminergic neurons, and the activation of microglial cells were all significantly improved by 2'-FL. 2'-FL also significantly down-regulated mRNA expression of Il-6 and Il-1β and alleviated oxidative damages through the Keap1-Nrf2 pathway to up-regulate Nqo1 expression. AD-increased PC (18:4/20:5) and DG (18:4/22:6/0:0) in the feces and serum were both decreased by 2'-FL, which was significantly positively correlated with inflammation and negatively correlated with synaptic plasticity. This study lays a theoretical basis for the application of 2'-FL in neurodegenerative diseases.

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来源期刊

Journal of Agricultural and Food Chemistry 农林科学-农业综合

CiteScore

9.90

自引率

8.20%

发文量

1375

审稿时长

2.3 months

期刊介绍： The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.