二氟烷基化喹啉[2,1-b]喹唑啉的芳基乙基喹啉-4(3H)- 1的光触发串联环化。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-09-26 DOI:10.1039/d5cc04514b

Haibo Yao, Qiyang Liu, Jinwei Yuan, Weixian Lv, Liangru Yang, Yongmei Xiao, Yuntao Xia, Dongliang Xing

引用次数: 0

摘要

研究了芳基乙基喹唑啉-4(3H)- 1与碘二氟乙酸乙酯或碘二氟酰胺的光诱导级联二氟烷基化/环化反应。这种转化可以通过连续的分子内双环化过程构建二氟烷基化喹诺啉[2,1-b]喹唑啉衍生物。它具有温和的反应条件，广泛的底物范围和中等至良好的产率。

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Photo-triggered tandem cyclization of arylethynyl quinazolin-4(3H)-one for difluoroalkylated quinolino[2,1-b]quinazolines.

A photoinduced cascade difluoroalkylation/cyclization reaction of arylethynyl quinazolin-4(3H)-ones with ethyl iododifluoroacetates or iododifluoramides has been developed. This transformation enables the construction of difluoroalkylated quinolino[2,1-b]quinazoline derivatives via consecutive intramolecular dual cyclization processes. It features mild reaction conditions, a broad substrate scope and moderate to good yields.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.