Muntha Chaudhari , Hafiz Anas Yahya , Jianming Pei , Gabriel J. DiNatale , Iryna Mahan , James Ryan Mark , Arthur S. Patchefsky , Matthew R. Zibelman , Shuanzeng Wei
{"title":"alk重排肾细胞癌伴7、17q染色体增加1例","authors":"Muntha Chaudhari , Hafiz Anas Yahya , Jianming Pei , Gabriel J. DiNatale , Iryna Mahan , James Ryan Mark , Arthur S. Patchefsky , Matthew R. Zibelman , Shuanzeng Wei","doi":"10.1016/j.eucr.2025.103219","DOIUrl":null,"url":null,"abstract":"<div><div>ALK-rearranged renal cell carcinoma (<em>ALK-</em>RCC) is a rare subtype of RCC. In this report we describe the first <em>ALK-</em>RCC with gains of chromosome 7 and 17q. A 39-year-old male presented with an 11.5 cm renal mass and underwent a left radical nephrectomy. The tumor cells demonstrate focal clear cytoplasm, papillary formation, and extensive sarcomatoid changes. Molecular tests showed <em>ALK</em> rearrangement and gains at chromosomes 7 and 17q, which are commonly seen in papillary renal cell carcinoma. Thus caution is advised when interpreting chromosomal alterations for renal cell carcinoma.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"63 ","pages":"Article 103219"},"PeriodicalIF":0.4000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ALK-rearranged renal cell carcinoma with gains of chromosomes 7 and 17q --- A case report\",\"authors\":\"Muntha Chaudhari , Hafiz Anas Yahya , Jianming Pei , Gabriel J. DiNatale , Iryna Mahan , James Ryan Mark , Arthur S. Patchefsky , Matthew R. Zibelman , Shuanzeng Wei\",\"doi\":\"10.1016/j.eucr.2025.103219\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>ALK-rearranged renal cell carcinoma (<em>ALK-</em>RCC) is a rare subtype of RCC. In this report we describe the first <em>ALK-</em>RCC with gains of chromosome 7 and 17q. A 39-year-old male presented with an 11.5 cm renal mass and underwent a left radical nephrectomy. The tumor cells demonstrate focal clear cytoplasm, papillary formation, and extensive sarcomatoid changes. Molecular tests showed <em>ALK</em> rearrangement and gains at chromosomes 7 and 17q, which are commonly seen in papillary renal cell carcinoma. Thus caution is advised when interpreting chromosomal alterations for renal cell carcinoma.</div></div>\",\"PeriodicalId\":38188,\"journal\":{\"name\":\"Urology Case Reports\",\"volume\":\"63 \",\"pages\":\"Article 103219\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2025-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Urology Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214442025002906\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214442025002906","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
ALK-rearranged renal cell carcinoma with gains of chromosomes 7 and 17q --- A case report
ALK-rearranged renal cell carcinoma (ALK-RCC) is a rare subtype of RCC. In this report we describe the first ALK-RCC with gains of chromosome 7 and 17q. A 39-year-old male presented with an 11.5 cm renal mass and underwent a left radical nephrectomy. The tumor cells demonstrate focal clear cytoplasm, papillary formation, and extensive sarcomatoid changes. Molecular tests showed ALK rearrangement and gains at chromosomes 7 and 17q, which are commonly seen in papillary renal cell carcinoma. Thus caution is advised when interpreting chromosomal alterations for renal cell carcinoma.
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