基于粘膜疫苗的细菌样颗粒（BLPs）的免疫学方面——最新综述

IF 3.5 3区医学 Q3 IMMUNOLOGY

Microbial pathogenesis Pub Date : 2025-09-19 DOI:10.1016/j.micpath.2025.108055

T.D. Phuong Nguyen , P. Thuan Cu , Teerajet Laohasatian , Thu-Dung Doan

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引用次数: 0

摘要

基于粘膜疫苗的细菌样颗粒（BLP）佐剂因其安全性，易于制备，优异的稳定性和有效的粘膜表面递送而得到认可。基于blp的粘膜疫苗的研制取得了显著进展。本文旨在全面了解目前BLP佐剂在疫苗开发中的应用，重点介绍其功效、有效性和佐剂作用机制。具体来说，这篇综述强调了BLP作为粘膜佐剂引发保护性和免疫反应的潜力。所提供的信息将为BLP在广泛宿主的疫苗接种策略中的应用提供最新和全面的见解。此外，本文还讨论了与BLP佐剂相关的潜在益处和挑战，旨在为未来的研究和疫苗设计工作提供有价值的建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Immunological aspects of mucosal vaccine-based bacterial-like particles (BLPs) – An updated review

Mucosal vaccine-based Bacterium-like particles (BLP) adjuvants are recognised for their safety, ease of preparation, excellent stability, and efficient delivery to mucosal surfaces. Remarkable progress has been achieved in the development of BLP-based mucosal vaccines. This review aims to provide a comprehensive understanding of the current application of BLP adjuvants in vaccine development, focusing on their efficacy, effectiveness, and mechanisms of adjuvanticity. Specifically, this review highlights the promising potential of BLP as a mucosal adjuvant to elicit protective and immune responses. The information presented will offer updated and thorough insights into the application of BLP in vaccination strategies for a wide range of hosts. Additionally, this review discusses the potential benefits and challenges associated with BLP adjuvants, aiming to provide valuable suggestions for future research and vaccine design efforts.

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来源期刊

Microbial pathogenesis 医学-免疫学

CiteScore

7.40

自引率

2.60%

发文量

472

审稿时长

56 days

期刊介绍： Microbial Pathogenesis publishes original contributions and reviews about the molecular and cellular mechanisms of infectious diseases. It covers microbiology, host-pathogen interaction and immunology related to infectious agents, including bacteria, fungi, viruses and protozoa. It also accepts papers in the field of clinical microbiology, with the exception of case reports. Research Areas Include: -Pathogenesis -Virulence factors -Host susceptibility or resistance -Immune mechanisms -Identification, cloning and sequencing of relevant genes -Genetic studies -Viruses, prokaryotic organisms and protozoa -Microbiota -Systems biology related to infectious diseases -Targets for vaccine design (pre-clinical studies)