血管干细胞衍生的胰岛:功能成熟的蓝图

IF 8.7 1区 生物学 Q1 CELL BIOLOGY
Yan Xiong, Per-Olof Berggren
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引用次数: 0

摘要

在这一期的《发育细胞》杂志上,Jun、Nguyen-Ngoc等人报道,将人类多能干细胞衍生的胰岛与内皮细胞和成纤维细胞结合,形成可灌注的微血管,加速了β细胞的功能成熟。内皮细胞来源的细胞外基质蛋白和BMP2/4增强了β细胞Ca2 +的响应、胰岛素分泌和体内移植性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vascularizing stem cell-derived islets: A blueprint for functional maturation
In this issue of Developmental Cell, Jun, Nguyen-Ngoc et al. report that embedding human pluripotent stem cell-derived islets with endothelial cells and fibroblasts, which form perfusable microvessels, accelerates β cell functional maturation. Endothelial cell-derived extracellular matrix proteins and BMP2/4 enhance the β cell Ca2⁺ response, insulin secretion, and in vivo graft performance.
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来源期刊
Developmental cell
Developmental cell 生物-发育生物学
CiteScore
18.90
自引率
1.70%
发文量
203
审稿时长
3-6 weeks
期刊介绍: Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.
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