Understanding miR-200c: an Important Player in Resistance to Cancer Treatment

One of the biggest obstacles to successful cancer treatment is still therapeutic resistance, which frequently leads to recurrence and unsatisfactory clinical outcomes. MicroRNA-200c (miR-200c), one of several molecular regulators, has grown into a crucial modulator of treatment efficacy by affecting processes including apoptosis, drug efflux, epithelial-mesenchymal transition, and cancer stem cell properties. Despite extensive research on miR-200c's roles in drug resistance, there is lack of comprehensive reviews summarizing these findings. This review gathers the most recent data on the complex functions of miR-200c in mediating chemotherapy and radiotherapy resistance across various cancer types. Its potential clinical aspects as a biomarker and therapeutic target are further discussed. Finally, existing knowledge gaps are outlined, and future research directions are proposed to support development of miR-200c-based strategies for overcoming therapeutic resistance in cancer.