{"title":"老年患者门周破骨细胞巨细胞癌的诊断:几次尝试的诊断挑战报告。","authors":"Sharifeh Almasaid, Fathima Keshia Suhail, Nesrine Bensaadi, Kelita Singh, Bishnu Sapkota","doi":"10.14309/crj.0000000000001829","DOIUrl":null,"url":null,"abstract":"<p><p>Cholangiocarcinoma is a rare gastrointestinal malignancy with an annual incidence of 0.3 to 6 cases per 100,000, and, usually, it is reported as adenocarcinoma in about 95% of the cases. It can develop as a result of combination of genetic predispositions and various risk factors like but not limited to choledochal cysts, cholelithiasis/choledocholithiasis, yet its diagnosis is challenging due to difficulties in obtaining tissue for diagnosis. In this study, we present a challenging case in diagnosis that reveals undifferentiated carcinoma with osteoclast-like giant cells in the perihilar region of the bile duct.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 9","pages":"e01829"},"PeriodicalIF":0.5000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440543/pdf/","citationCount":"0","resultStr":"{\"title\":\"Diagnosis of Perihilar Osteoclast Giant Cell Carcinoma in an Elderly Patient: A Report of Diagnostic Challenges Over Several Attempts.\",\"authors\":\"Sharifeh Almasaid, Fathima Keshia Suhail, Nesrine Bensaadi, Kelita Singh, Bishnu Sapkota\",\"doi\":\"10.14309/crj.0000000000001829\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cholangiocarcinoma is a rare gastrointestinal malignancy with an annual incidence of 0.3 to 6 cases per 100,000, and, usually, it is reported as adenocarcinoma in about 95% of the cases. It can develop as a result of combination of genetic predispositions and various risk factors like but not limited to choledochal cysts, cholelithiasis/choledocholithiasis, yet its diagnosis is challenging due to difficulties in obtaining tissue for diagnosis. In this study, we present a challenging case in diagnosis that reveals undifferentiated carcinoma with osteoclast-like giant cells in the perihilar region of the bile duct.</p>\",\"PeriodicalId\":7394,\"journal\":{\"name\":\"ACG Case Reports Journal\",\"volume\":\"12 9\",\"pages\":\"e01829\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2025-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440543/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACG Case Reports Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14309/crj.0000000000001829\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACG Case Reports Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14309/crj.0000000000001829","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Diagnosis of Perihilar Osteoclast Giant Cell Carcinoma in an Elderly Patient: A Report of Diagnostic Challenges Over Several Attempts.
Cholangiocarcinoma is a rare gastrointestinal malignancy with an annual incidence of 0.3 to 6 cases per 100,000, and, usually, it is reported as adenocarcinoma in about 95% of the cases. It can develop as a result of combination of genetic predispositions and various risk factors like but not limited to choledochal cysts, cholelithiasis/choledocholithiasis, yet its diagnosis is challenging due to difficulties in obtaining tissue for diagnosis. In this study, we present a challenging case in diagnosis that reveals undifferentiated carcinoma with osteoclast-like giant cells in the perihilar region of the bile duct.
期刊介绍:
ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.