Qiu-Zhu Chen, Yue-Qi Jiang, Gen Li, Cai-Xia Zang, Jing-Wei Ma, Yang Yang, Yi-Rong Dong, Jin-Rong Wang, Ning Zhou, Xing Yang, Fang-Fang Li, Xiu-Qi Bao, Dan Zhang
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Network pharmacology analysis and experimental validation of Yinma Jiedu Granule in the treatment of acute pharyngitis.
Yinma Jiedu Granules (YMJD) is a classical Chinese medicinal formula for alleviating inflammatory conditions, such as acute bronchitis and tracheitis. In this study, network pharmacology identified AKT1, IL6, and IL1B as hub genes, and molecular docking confirmed their binding to active ingredients (naringenin, quercetin, and aloe-emodin). Moreover, pathway enrichment analysis indicated YMJD alleviated acute pharyngitis by suppressing oxidative stress and PI3K-AKT signaling pathway. In acute pharyngitis rat model, YMJD improved the symptoms of acute pharyngitis. Mechanistic study showed that YMJD inhibited oxidative stress and inflammatory response through downregulation of PI3K/AKT/mTOR signaling pathway, providing evidence for YMJD to treat acute pharyngitis.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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