临床实践中从业者对重症肌无力管理建议的看法:一项横断面调查研究。

IF 2.8 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Therapeutic Advances in Chronic Disease Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI:10.1177/20406223251368063
Elena Cortés-Vicente, Antonio Guerrero-Sola, Fernando Caballero-Martínez, Francisco Javier Campos-Lucas, Juan Gómez-Salgado, Diana Monge-Martín, Rodrigo Álvarez-Velasco
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引用次数: 0

摘要

背景:重症肌无力(MG)是一种慢性、波动性疾病,其独特的自然病史使治疗试验的设计复杂化。许多MG管理建议所依据的证据是有限的。目的:确定国际公认的MG管理建议在实际实践中的知识、共识和应用程度。设计:对专攻MG的西班牙神经科医生进行横断面调查。方法:调查评估知识,协议和应用的建议,以及与美国重症肌无力基金会的国际共识定义的一致程度。结果:53名神经科医生(平均年龄45.4岁,53%为男性)平均每天治疗3.6例MG患者。在61项建议中的40项中,至少90%的神经科医生知道该建议。最不为人所知的建议涉及青少年和怀孕期间的MG。两项建议(妊娠期MG和轻度或眼部MG静脉注射免疫球蛋白)没有达成多数一致意见。除了血浆置换、胸腺切除术、甲氨蝶呤或依珠单抗相关的建议外,建议的执行情况很高。结论:这些建议是众所周知的,一致同意的,并得到了应用。然而,证据、共识和知识传播方面需要加强,如青少年MG管理、妊娠MG或某些治疗方法的使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Practitioner's perception of myasthenia gravis management recommendations in clinical practice: a cross-sectional survey study.

Practitioner's perception of myasthenia gravis management recommendations in clinical practice: a cross-sectional survey study.

Practitioner's perception of myasthenia gravis management recommendations in clinical practice: a cross-sectional survey study.

Practitioner's perception of myasthenia gravis management recommendations in clinical practice: a cross-sectional survey study.

Background: Myasthenia gravis (MG) is a chronic, fluctuating disease whose unique natural history complicates designing therapeutic trials. The evidence on which many MG management recommendations are based is limited.

Objective: To determine the degree of knowledge, agreement, and application of internationally recognized recommendations for managing MG in actual practice.

Design: A cross-sectional survey was conducted among Spanish neurologists specializing in MG.

Methods: The survey assessed knowledge, agreement, and application of recommendations, along with the degree of agreement with international consensus definitions from the Myasthenia Gravis Foundation of America.

Results: Fifty-three neurologists (mean age 45.4 years, 53% men) attended an average of 3.6 patients with MG daily. In 40 out of 61 recommendations, at least 90% of the neurologists were aware of the recommendation. The least known recommendations dealt with juvenile MG and MG in pregnancy. There was no majority agreement in two recommendations (for MG in pregnancy and the use of intravenous immunoglobulin in mild or ocular MG). The implementation of the recommendations was high except for the ones related to plasma exchange, thymectomy, methotrexate, or eculizumab.

Conclusion: The recommendations are well-known, agreed upon, and applied. However, the evidence, consensus, and knowledge dissemination need reinforcement regarding aspects such as the management of juvenile MG, MG in pregnancy, or the use of certain treatments.

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来源期刊
Therapeutic Advances in Chronic Disease
Therapeutic Advances in Chronic Disease Medicine-Medicine (miscellaneous)
CiteScore
6.20
自引率
0.00%
发文量
108
审稿时长
12 weeks
期刊介绍: Therapeutic Advances in Chronic Disease publishes the highest quality peer-reviewed research, reviews and scholarly comment in the drug treatment of all chronic diseases. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers involved in the medical treatment of chronic disease, providing a forum in print and online for publishing the highest quality articles in this area.
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