定义禽原始生殖细胞发育的转录组谱。

IF 1.2 4区生物学 Q4 BIOCHEMICAL RESEARCH METHODS

Protein expression and purification Pub Date : 2025-09-11 DOI:10.1016/j.pep.2025.106812

Kennosuke Ichikawa, Mike J. McGrew

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引用次数: 0

摘要

鸟类生物学对可持续蛋白质生产、内分泌学、发育生物学、神经科学和免疫学等许多研究领域做出了贡献。原始生殖细胞，即谱系限制型干细胞，是保护鸟类遗传多样性、研究生殖细胞发育和建立鸟类生物学遗传模型的关键。在这里，我们回顾了目前对鸟类原始生殖细胞发育和命运决定过程的了解，重点介绍了基因表达谱揭示的见解。我们总结了鸡原始细胞生长的特点和基本途径。此外，我们还讨论了与其他鸟类相比，鸡PGCs的共同和不同特征。这些见解对生殖细胞生物学、生殖生物技术和鸟类遗传保护的研究人员有价值，并表明需要进一步分析鸟类物种。

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Transcriptome profiles for defining avian primordial germ cell development

Avian biology has contributed to many research areas, such as sustainable protein production, endocrinology, developmental biology, neurosciences, and immunology. Primordial germ cells, lineage-restricted stem cells, are key for the conservation of genetic diversity of bird species, as well as for studying germ cell development and producing genetic models to study avian biology. Here, we review the current knowledge of developmental and fate decision processes in avian primordial germ cells focusing on insights revealed by gene expression profiling. We summarized the characteristics and fundamental pathways required for chicken primordial cell growth. In addition, we discuss the common and disparate features of PGCs from chicken compared to other avian species. These insights are valuable for researchers in germ cell biology, reproductive biotechnology, and avian genetic conservation and indicate a need for the analysis of further bird species.

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来源期刊

Protein expression and purification 生物-生化研究方法

CiteScore

3.70

自引率

6.20%

发文量

120

审稿时长

32 days

期刊介绍： Protein Expression and Purification is an international journal providing a forum for the dissemination of new information on protein expression, extraction, purification, characterization, and/or applications using conventional biochemical and/or modern molecular biological approaches and methods, which are of broad interest to the field. The journal does not typically publish repetitive examples of protein expression and purification involving standard, well-established, methods. However, exceptions might include studies on important and/or difficult to express and/or purify proteins and/or studies that include extensive protein characterization, which provide new, previously unpublished information.