碳酸酐酶ix靶向铜掺杂碳点作为治疗三阴性乳腺癌的治疗探针

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-09-10 DOI:10.1039/d5cc04653j

Aftab Hossain Khan , Sudeshna Pal , Prasanta Kumar Das

引用次数: 0

摘要

在此，我们展示了碳酸酐酶ix靶向乙酰唑胺功能化铜掺杂碳点（CuCD-Az）对三阴性乳腺癌（TNBC）细胞的选择性诊断和化学动力学治疗。CuCD-Az通过fenton样反应介导的ROS介导的细胞凋亡，对TNBC的细胞毒性比正常细胞高3倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Carbonic anhydrase-IX targeted copper-doped carbon dots as a theranostic probe for treating triple negative breast cancer

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Carbonic anhydrase-IX targeted copper-doped carbon dots as a theranostic probe for treating triple negative breast cancer

Herein, we demonstrate selective diagnosis and chemodynamic therapy in triple negative breast cancer (TNBC) cells by carbonic anhydrase-IX targeted acetazolamide-functionalized copper-doped carbon dots (). showed ∼3-fold higher cytotoxicity to TNBC compared to normal cells by ROS-mediated apoptosis via Fenton-like reaction.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.