骨肉瘤的程序性细胞死亡：凋亡、铁下垂和焦下垂

IF 2.5 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences Pub Date : 2025-09-08 DOI:10.1016/j.jrras.2025.101936

Zhaoyan Ding , Yunping Li , Guijun Zhang , Yuanming Yang

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引用次数: 0

摘要

骨肉瘤（Osteosarcoma， OS）是儿童和青少年最常见的原发性恶性骨肿瘤，具有高侵袭性和转移潜力。新辅助化疗、手术和靶向治疗序贯治疗形成标准治疗。放疗用于不可切除的肿瘤或边缘阳性切除，因为其在OS中的疗效有限。细胞程序性死亡（PCD）在机体生长发育过程中起着至关重要的作用，受多种基因调控。值得注意的是，除了凋亡外，铁下垂和焦下垂也参与了OS的发展。本文综述了OS中细胞凋亡、铁下垂和焦下垂的调控机制，并重点讨论了新的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Programmed cell death in osteosarcoma: apoptosis, ferroptosis and pyroptosis

Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, characterized by high aggressiveness and metastatic potential. Sequential treatment with neoadjuvant chemotherapy, surgery, and targeted therapy forms the standard care. Radiotherapy is reserved for unresectable tumours or margin-positive resections, given its limited efficacy in OS. Programmed cell death (PCD) plays a crucial role in bodily growth and development and is regulated by numerous genes. It is noteworthy that in addition to apoptosis, ferroptosis and pyroptosis are also involved in the development of OS. This review provides an overview of the regulatory mechanisms of apoptosis, ferroptosis and pyroptosis in OS, with a focus on developing new therapeutic strategies of this disease.

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来源期刊

Journal of Radiation Research and Applied Sciences MULTIDISCIPLINARY SCIENCES-

自引率

5.90%

发文量

130

审稿时长

16 weeks

期刊介绍： Journal of Radiation Research and Applied Sciences provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and applications of nuclear, radiation and isotopes in biology, medicine, drugs, biochemistry, microbiology, agriculture, entomology, food technology, chemistry, physics, solid states, engineering, environmental and applied sciences.