Diversified Synthetic Strategies of Quinoline and Its Derivatives: A Review

Quinoline is one of the heterocyclic scaffolds that have nitrogen at the first position. Recently, quinoline scaffolds were found to play a vital role in medicinal chemistry due to their low cytotoxicity and diverse biological applications. Heterocycles quinoline compounds have shown a wide spectrum of pharmacological activities that have been successfully screened for anti-inflammatory, anticancer, antimalarial, and antibacterial potency. Due to the biological and pharmacological activities of quinoline and their derivatives, several different strategies have been developed for the synthesis of the ring. This article aims to highlight syntheses using various protocols for the development of quinoline derivatives.