黄杨中的三萜生物碱及其生物活性研究

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-09-02 DOI:10.1016/j.tetlet.2025.155815

Hong-Jing Zha , Chun-Xia Chen , Xing Sun , Shi-Ying Yuan

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引用次数: 0

摘要

从黄杨的细枝和叶片的甲醇提取物中分离出4个新的三萜生物碱（1-4）和5个已知的类似物（5-9）。它们的结构是通过对光谱数据的广泛分析确定的，并由单晶x射线衍射证实。在lps诱导的RAW264.7细胞模型中，化合物1和2的抗炎作用最强，IC50值分别为7.5 μM和6.1 μM。化合物2和6对HT-29细胞株的IC50分别为6.4和10.2 μM，分别比阳性对照顺铂（IC50 = 18.6 μM）高2.9倍和1.8倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Triterpenoid alkaloids from Buxus bodinieri and their bioactivities

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Triterpenoid alkaloids from Buxus bodinieri and their bioactivities

Phytochemical investigation of a methanol extract of the twigs and leaves of Buxus bodinieri led to the isolation of four new triterpenoid alkaloids (1–4) and five known analogues (5–9). Their structures were determined by extensive analyses of their spectroscopic data and corroborated by the single-crystal X-ray diffraction. In LPS-induced RAW264.7 cells model, compounds 1 and 2 displayed the most potent anti-inflammatory effects, with IC₅₀ values of 7.5 and 6.1 μM, respectively. Compounds 2 and 6 also exhibited significant cytotoxic activity against HT-29 cell line (IC50 of 6.4 and 10.2 μM), representing 2.9-fold and 1.8-fold greater potency than the positive control cisplatin (IC₅₀ = 18.6 μM), respectively.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.