从缓冲到罪魁祸首：心外膜脂肪组织在心血管疾病中的作用。

IF 2.2 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart, Lung and Circulation Pub Date : 2025-10-01 DOI:10.1016/j.hlc.2025.07.010

Shaun Khanna MBBS, MMed, FRACP , Gurkeerat Mann MD , Sheran Vasanthakumar MBBS, FRACP , Clare Arnott MBBS, PhD, FRACP , Nitesh Nerlekar MBBS, PhD, FRACP

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引用次数: 0

摘要

心外膜脂肪组织（EAT）是位于内脏心包和心肌之间的脂肪层。新兴研究表明，它在各种心血管疾病的发展中起着重要作用。其发病机制很复杂，涉及多种生物活性化合物，这些化合物与冠状动脉疾病、心力衰竭和心律失常的发生有关。评估EAT的最佳成像方式是心脏计算机断层扫描，它允许体积和密度测量反映EAT的动态性质。EAT可以通过生活方式干预、药物策略和手术治疗来调节，强调了其作为治疗靶点的潜力。这篇综述旨在总结当代对EAT的生理、测量、病理和治疗机会的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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From Cushion to Culprit: The Role of Epicardial Adipose Tissue in Cardiovascular Disease

Epicardial adipose tissue (EAT) is the layer of fat located between the visceral pericardium and the myocardium. Emerging research has signified its role in the development of various cardiovascular diseases. The pathogenesis is complex, involving various bioactive compounds that have been implicated in the development of coronary artery disease, heart failure, and arrhythmogenesis. The optimal imaging modality for assessing EAT is cardiac computed tomography, which allows both volumetric and density measurement reflective of the dynamic nature of EAT. EAT can be modulated through lifestyle interventions, pharmacological strategies, and surgical therapies, underscoring its potential as a therapeutic target. This review aims to summarise the contemporary understanding of the physiology, measurement, pathology, and treatment opportunities for EAT.

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来源期刊

Heart, Lung and Circulation CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.50

自引率

3.80%

发文量

912

审稿时长

11.9 weeks

期刊介绍： Heart, Lung and Circulation publishes articles integrating clinical and research activities in the fields of basic cardiovascular science, clinical cardiology and cardiac surgery, with a focus on emerging issues in cardiovascular disease. The journal promotes multidisciplinary dialogue between cardiologists, cardiothoracic surgeons, cardio-pulmonary physicians and cardiovascular scientists.