类风湿性关节炎:分子机制和靶向免疫治疗的新见解。

IF 3.4 4区 医学 Q2 RHEUMATOLOGY
Weiming Yang, Juanjuan Chen, Xiaozhong Wang
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引用次数: 0

摘要

类风湿性关节炎(RA)是一种慢性、全身性、自身免疫性炎症疾病,其特征是滑膜关节持续炎症,最终导致进行性关节破坏和严重的残疾。对严重关节炎无效的药物治疗会导致严重的身体残疾和生活质量的显著下降。最近的研究大大提高了我们对类风湿性关节炎潜在分子机制的理解,这导致了新的免疫治疗策略的出现,为患者提供了更广泛的治疗选择。本文综述了类风湿性关节炎的分子机制、相关信号通路和最新的免疫治疗方法,包括生物制剂、靶向小分子和新疗法。此外,我们将讨论这些疗法的疗效和安全性概况,分析当代研究中的紧迫问题,并探讨该领域的未来方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rheumatoid arthritis: emerging insights into molecular mechanisms and targeted immunotherapy.

Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune inflammatory disease that characterised by persistent synovial joints inflammation, which ultimately results in progressive joint destruction and significant disability. Ineffective drug treatment for severe arthritis can lead to significant physical disability and a marked decline in quality of life. Recent research has significantly advanced our understanding of the underlying molecular mechanisms of RA, which leads to the emergence of novel immunotherapeutic strategies that provide patients with a broader range of treatment options. This review aims to synthesise the current knowledge of the molecular mechanisms of RA, related signalling pathways, and the latest immunotherapy approaches, including biologic agents, targeted small molecules, and novel therapies.Furthermore, we will discuss the efficacy and safety profiles of these therapies, analyse pressing issues in contemporary research, and explore future directions in the field.

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来源期刊
CiteScore
6.10
自引率
18.90%
发文量
377
审稿时长
3-6 weeks
期刊介绍: Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.
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