VNS治疗双侧局灶性额叶癫痫的不对称疗效1例

IF 1.9 3区医学 Q3 CLINICAL NEUROLOGY

Acta Neurochirurgica Pub Date : 2025-08-26 DOI:10.1007/s00701-025-06653-x

Masanobu Kumon, Shunsuke Nakae, Daijiro Kojima, Noeru Kawase, Yuichi Hirose

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引用次数: 0

摘要

迷走神经刺激（VNS）的偏侧效应尚未得到充分探讨。我们报告一例伴有双侧额叶癫痫发作的耐药癫痫，用左颈VNS治疗。术前视频脑电图显示主要的间歇放电在右半球和频繁的癫痫发作从两个半球。迷走神经刺激后，癫痫发作的总体频率下降。值得注意的是，术后15个月进行的立体脑电图显示右侧癫痫发作明显减少，而左侧癫痫发作仍然频繁。本病例强调了VNS在单个双侧额叶癫痫患者中潜在的偏侧效应，表明VNS可能优先抑制源自右半球的癫痫发作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Asymmetric efficacy of VNS within a single patient with bilateral focal frontal lobe epilepsy: A case report

The lateralized efficacy of vagus nerve stimulation (VNS) remains insufficiently explored. We report a case of drug-resistant epilepsy with bilateral frontal lobe seizure onset, treated with left cervical VNS. Preoperative video- electroencephalogram revealed predominant interictal discharges in the right hemisphere and frequent seizures from both hemispheres. Following VNS, overall seizure frequency decreased. Notably, stereo-electroencephalography performed 15 months postoperatively showed a marked reduction in right-sided seizures, while left-sided seizures remained frequent. This case highlights the potential lateralized effect of VNS in a single patient with bilateral frontal lobe epilepsy, suggesting that VNS may preferentially suppress seizures originating from the right hemisphere.

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来源期刊

Acta Neurochirurgica 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

342

审稿时长

1 months

期刊介绍： The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.