Synthesis of phenyl carboxylates via molybdenum carbonyl-mediated carbonylation of phenols and iodides under mild conditions

A novel and efficient method for the synthesis of phenyl carboxylates via carbonylation of phenols and iodides using molybdenum carbonyl as the carbonyl source under mild conditions is reported. This research avoids the use of toxic and high-pressure CO gas by employing Mo(CO)₆ as a stoichiometric, controlled CO source, reducing safety risks associated with high-pressure CO storage and handling. By optimizing reaction parameters, a variety of phenyl carboxylates were obtained in good to excellent yields with broad substrate compatibility. Mechanistic studies revealed the N-acyl DBU iodine salt was synthesized during the reaction process. This work provides a practical alternative for phenyl carboxylate synthesis and expands the application of molybdenum carbonyl in carbonylation reactions.