基于狂犬病的高致病性甲型流感病毒H5疫苗在牛体内的免疫原性和安全性。

IF 6.5 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2025-08-19 DOI:10.1038/s41541-025-01238-2

Nir Paran, Christoph Wirblich, Catherine Olal, Alessandro Tarquinio, Kimberly H Lohmeyer, Drishya Kurup, Stacey Schultz-Cherry, Ismaila Shittu, Gregory C Gray, Dennis A Bente, Pia U Olafson, Matthias J Schnell

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引用次数: 0

摘要

高致病性H5甲型流感病毒在牛、其他哺乳动物和野生动物中的传播威胁着动物和人类的健康。为了解决这个问题，我们给小牛接种了一种灭活的基于狂犬病病毒的H5疫苗，该疫苗耐受性良好，并引发了针对clade-1和clade-2.3.4.4b H5N1病毒的中和抗体，与自然感染H5和康复的奶牛相当。对疫苗平台的免疫反应至少持续200天，不受先前存在的RABV免疫的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle.

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Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle.

The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.