自体脐带血移植治疗特发性重度再生障碍性贫血。

IF 0.8 4区医学 Q4 HEMATOLOGY

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-11 DOI:10.1097/MPH.0000000000003106

Anselm Chi-Wai Lee

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引用次数: 0

摘要

脐带血很少用于自体移植，选择标准尚未明确。一例患有严重再生障碍性贫血的6岁男性接受了含总有核细胞（TNC） 2.0×107/kg和CD34+0.32×105/kg的自体脐带血移植。然而，他失去了移植物，并通过第二个单倍体相同的供体移植物获救。加上文献报道，15例再生障碍性贫血患儿接受了自体脐带血移植。13个孩子成功了，2个失败了。TNC剂量>2.5×107/kg可预测移植成功（12/12 vs. 1/3； P=0.029），而CD34+剂量和患者年龄不能预测移植成功。具有足够TNC的脐带血单位是自体移植的有效产品。

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Autologous Cord Blood Transplantation for Idiopathic Severe Aplastic Anemia.

Cord blood units are seldom used for autologous transplantation and selection criteria have not been defined. A 6-year-old male with severe aplastic anemia received an autologous cord blood transplantation containing total nucleated cells (TNC) 2.0×107/kg and CD34+0.32×105/kg. However, he lost the graft and was rescued with a second, haploidentical donor graft. Together with those reported in the literature, 15 children with aplastic anemia received autologous cord blood transplantation. Thirteen children succeeded but 2 failed. Successful transplantation can be predicted by TNC doses of >2.5×107/kg (12/12 vs. 1/3; P=0.029), but not by CD34+ dose or patient's age. Cord blood units with adequate TNC are valid products for autologous transplantation.

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来源期刊

Journal of Pediatric Hematology/Oncology 医学-小儿科

CiteScore

1.90

自引率

8.30%

发文量

415

审稿时长

2.5 months

期刊介绍： Journal of Pediatric Hematology/Oncology (JPHO) reports on major advances in the diagnosis and treatment of cancer and blood diseases in children. The journal publishes original research, commentaries, historical insights, and clinical and laboratory observations.