高压氧治疗骨骼肌损伤临床前模型的范围回顾和评价。

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Medical Gas Research Pub Date : 2026-06-01 Epub Date: 2025-08-18 DOI:10.4103/mgr.MEDGASRES-D-24-00163
Barbara St Pierre Schneider, Liyuan Zhang, Thomas Dombrowsky, Judy R Wilson
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引用次数: 0

摘要

虽然高压氧治疗(HBOT)有望减轻肢体创伤或挤压性肌肉损伤,但缺乏相关科学状况的批判性检查。我们在临床前模型中对HBOT对肌肉损伤的影响进行了范围审查和评估。对PubMed和Web of Science数据库的搜索显示,从数据库开始到2024年11月7日,共发表了157篇报告,在删除重复、非肌肉研究和论文/评论后,减少到19篇。这些研究用止血带或暴露于肌毒剂(布比卡因和心脏毒素)或挤压来诱导肌肉损伤的小鼠或大鼠。在止血带模型中,HBOT抵消了代谢作用,对氧化应激有不同的影响。总的来说,HBOT促进或加速了由肌毒素和挤压引起的肌肉再生。这些发现还表明,HBOT的益处可能持续存在,早期开始HBOT是重要的。然而,更多的会议并不总是产生更好的结果。对科学状况的评估显示,将女性纳入这些研究是有限的,并且对较轻的压力水平进行了充分的测试,这可能对减少不良影响和获取很重要。未来在这些和其他领域的研究可能会增加HBOT在肢体创伤或挤压性肌肉损伤治疗中的应用和可接受性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A scoping review and evaluation of hyperbaric oxygen therapy for skeletal muscle injury in preclinical models.

A scoping review and evaluation of hyperbaric oxygen therapy for skeletal muscle injury in preclinical models.

A scoping review and evaluation of hyperbaric oxygen therapy for skeletal muscle injury in preclinical models.

Although hyperbaric oxygen therapy (HBOT) is promising for the alleviation of limb trauma or crush muscle injuries, critical examination of the state of related science is lacking. We conducted a scoping review and evaluation of HBOT on muscle injury in preclinical models. A search of PubMed and Web of Science databases yielded 157 reports published from the start of the databases until November 7, 2024, which narrowed to 19 after removing duplicates, non-muscle studies, and dissertations/reviews. The studies involved mice or rats treated with tourniquets or exposed to a myotoxic agent (bupivacaine and cardiotoxin) or crush to induce muscle injury. HBOT counteracted metabolic effects and had differential effects on oxidative stress in the tourniquet model. Overall, HBOT promoted or quickened muscle regeneration initiated by myotoxic agents and crush. These findings also indicate that HBOT benefits may persist, and early initiation of HBOT is important. However, more sessions do not always yield better outcomes. The evaluation of the state of the science revealed that the inclusion of females in these studies is limited, and milder pressure levels have been undertested, which may be important for fewer adverse effects and access. Future research in these and other areas may lead to increased use and acceptability of HBOT for the treatment of limb trauma or crush muscle injuries.

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来源期刊
Medical Gas Research
Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
5.10
自引率
13.80%
发文量
35
期刊介绍: Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.
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