可见光介导的一锅法合成2,5-二取代1,3,4-恶二唑

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2025-06-26 DOI:10.1002/jhet.4950

Satya Narayana Gondu, Shahadat Ahmed, B. Narayana, Madan Kumar S

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引用次数: 0

摘要

在温和条件下，采用一定量的光催化剂，建立了一锅三组分光氧化还原法合成2,5-二取代1,3,4-恶二唑衍生物。该方法包括可见光介导异硫氰酸酯与肼的偶联，随后在烷基卤化物的帮助下分子内环化以形成所需的取代的恶二唑分子。该方法已被优化为广泛的底物，并产生中等到良好的产率。该方法的简单和高效使其成为合成结构有趣的分子的有用工具，用于各种应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible Light Mediated One Pot Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazole

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Visible Light Mediated One Pot Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazole

A one-pot, three-component photo redox process has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives under mild conditions using a catalytic amount of photocatalyst. The method involves the visible light-mediated coupling of isothiocyanates with hydrazines, followed by intramolecular cyclization with the aid of an alkyl halide to form the desired substituted oxadiazole molecule. The method has been optimized for a wide range of substrates and produces moderate to good yields. The simplicity and efficiency of this method make it a useful tool for the synthesis of structurally interesting molecules for various applications.

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.