凝集素在炎症性皮肤病中的作用及未来发展方向。

IF 7.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2025-08-13 DOI:10.1016/j.drudis.2025.104455

Mab P. Corrêa , Rebeca D. Correia-Silva , Diego D. Santos , Karin V. Greco , Cristiane D. Gil

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引用次数: 0

摘要

半乳糖凝集素（LGALS）是β-半乳糖苷结合的凝集素，参与免疫调节、上皮完整性和组织重塑。在皮肤中，它们在角质形成细胞、成纤维细胞和免疫细胞中表现出细胞类型特异性表达，形成炎症信号和屏障稳态。在这篇综述中，我们研究了LGALS在炎症性皮肤病中的表达和功能，重点是特应性皮炎（AD）和牛皮癣（Pso）。在AD中，LGALS1、-3、-7、-9和-10与Th2/Th22反应和屏障功能障碍有关。在Pso中，LGALS1、-3和-7的减少与lgals8的增殖作用和LGALS9的免疫调节作用形成对比。这些发现突出了LGALS的诊断和治疗潜力，支持了它们在精准医学和慢性皮肤炎症靶向治疗方面的相关性。

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Galectins in inflammatory skin diseases: current roles and future directions

Galectins (LGALS) are β-galactoside-binding lectins involved in immune regulation, epithelial integrity, and tissue remodeling. In the skin, they exhibit cell type-specific expression across keratinocytes, fibroblasts, and immune cells, shaping inflammatory signaling and barrier homeostasis. In this review, we examine LGALS expression and function in inflammatory skin diseases, with a focus on atopic dermatitis (AD) and psoriasis (Pso). In AD, LGALS1, -3, -7, -9, and -10 are linked to Th2/Th22 responses and barrier dysfunction. In Pso, reduced LGALS1, -3, and -7 contrast with the proproliferative effects of LGAS-8 and immunomodulatory role of LGALS9. These findings highlight the diagnostic and therapeutic potential of LGALS, supporting their relevance in precision medicine and targeted approaches for chronic skin inflammation.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.