{"title":"儿童格雷夫斯病：临床特征和治疗结果的见解","authors":"Akshatha Anand, Vani Hebbal Nagarajappa, Raghupathy Palany","doi":"10.20945/2359-4292-2025-0017","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To identify early manifestations of Graves' disease in young patients and its treatment outcomes.</p><p><strong>Subjects and methods: </strong>This was a hospital-based review of case records of 47 children (aged 1 month to 18 years) with Graves' disease from 2011 to 2022. Data were summarized and statistically analyzed.</p><p><strong>Results: </strong>This study included 47 patients with Graves' disease, of whom 31 (66%) were girls. The average age at the initial diagnosis was 12.79 ± 3.75 years. Common presenting complaints included heat intolerance (76.6%), excessive sweating (74.5%), palpitations (68.1%), tremors (48.9%), weight loss (38.3%), increased appetite (34%), diarrhea (31.9%), and constipation (4.3%). The mean thyrotropin receptor antibody titer was 16.93 ± 13.47 IU/L. Remission was achieved in two (4.3%) patients treated with antithyroid drugs.</p><p><strong>Conclusion: </strong>Graves' disease is the most common cause of juvenile hyperthyroidism, and treating physicians should be aware of its signs and symptoms to avoid treatment delays.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483166/pdf/","citationCount":"0","resultStr":"{\"title\":\"Pediatric Graves' disease: insights into clinical characteristics and treatment outcomes.\",\"authors\":\"Akshatha Anand, Vani Hebbal Nagarajappa, Raghupathy Palany\",\"doi\":\"10.20945/2359-4292-2025-0017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To identify early manifestations of Graves' disease in young patients and its treatment outcomes.</p><p><strong>Subjects and methods: </strong>This was a hospital-based review of case records of 47 children (aged 1 month to 18 years) with Graves' disease from 2011 to 2022. Data were summarized and statistically analyzed.</p><p><strong>Results: </strong>This study included 47 patients with Graves' disease, of whom 31 (66%) were girls. The average age at the initial diagnosis was 12.79 ± 3.75 years. Common presenting complaints included heat intolerance (76.6%), excessive sweating (74.5%), palpitations (68.1%), tremors (48.9%), weight loss (38.3%), increased appetite (34%), diarrhea (31.9%), and constipation (4.3%). The mean thyrotropin receptor antibody titer was 16.93 ± 13.47 IU/L. Remission was achieved in two (4.3%) patients treated with antithyroid drugs.</p><p><strong>Conclusion: </strong>Graves' disease is the most common cause of juvenile hyperthyroidism, and treating physicians should be aware of its signs and symptoms to avoid treatment delays.</p>\",\"PeriodicalId\":54303,\"journal\":{\"name\":\"Archives of Endocrinology Metabolism\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-08-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483166/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Endocrinology Metabolism\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.20945/2359-4292-2025-0017\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Endocrinology Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.20945/2359-4292-2025-0017","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Pediatric Graves' disease: insights into clinical characteristics and treatment outcomes.
Objective: To identify early manifestations of Graves' disease in young patients and its treatment outcomes.
Subjects and methods: This was a hospital-based review of case records of 47 children (aged 1 month to 18 years) with Graves' disease from 2011 to 2022. Data were summarized and statistically analyzed.
Results: This study included 47 patients with Graves' disease, of whom 31 (66%) were girls. The average age at the initial diagnosis was 12.79 ± 3.75 years. Common presenting complaints included heat intolerance (76.6%), excessive sweating (74.5%), palpitations (68.1%), tremors (48.9%), weight loss (38.3%), increased appetite (34%), diarrhea (31.9%), and constipation (4.3%). The mean thyrotropin receptor antibody titer was 16.93 ± 13.47 IU/L. Remission was achieved in two (4.3%) patients treated with antithyroid drugs.
Conclusion: Graves' disease is the most common cause of juvenile hyperthyroidism, and treating physicians should be aware of its signs and symptoms to avoid treatment delays.
期刊介绍：
The Archives of Endocrinology and Metabolism - AE&M – is the official journal of the Brazilian Society of Endocrinology and Metabolism - SBEM, which is affiliated with the Brazilian Medical Association.
Edited since 1951, the AE&M aims at publishing articles on scientific themes in the basic translational and clinical area of Endocrinology and Metabolism. The printed version AE&M is published in 6 issues/year. The full electronic issue is open access in the SciELO - Scientific Electronic Library Online e at the AE&M site: www.aem-sbem.com.
From volume 59 on, the name was changed to Archives of Endocrinology and Metabolism, and it became mandatory for manuscripts to be submitted in English for the online issue. However, for the printed issue it is still optional for the articles to be sent in English or Portuguese.
The journal is published six times a year, with one issue every two months.
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