恒河奈瑟菌感染性心内膜炎：中国首例报告

IF 1.8 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-08-07 DOI:10.1016/j.diagmicrobio.2025.117055

Yanjun Zhang, Dong Yang, Wei Wang

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引用次数: 0

摘要

背景：macacae奈瑟菌是一种很少涉及人类疾病的革兰氏阴性双球菌。病例介绍：我们报告一例感染性心内膜炎在一个60岁的男性间歇性发烧。体格检查发现收缩期杂音。实验室检查显示明显的炎症。心脏超声显示三尖瓣赘生物。通过VITEK 2 COMPACT、MALDI-TOF MS和16S rRNA测序，血液培养结果为猕猴N. macacae阳性。该细菌对头孢曲松和美罗培南敏感。最初用美罗培南治疗，然后在病原体鉴定和药敏试验后加入头孢曲松，炎症标志物明显改善。随后的三尖瓣手术成功。结论：该病例强调了在不明原因发热或感染性心内膜炎中考虑猕猴的必要性，并强调了先进微生物鉴定技术的价值。

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Neisseria macacae infective endocarditis: first case report in China

Background

: Neisseria macacae is a gram‑negative diplococcus rarely implicated in human disease.

Case Presentation

: We report a case of infective endocarditis in a 60-year-old male with intermittent fever. Physical examination revealed a systolic murmur. Laboratory tests showed significant inflammation. Cardiac ultrasound demonstrated a tricuspid valve vegetation. Blood cultures were positive for N. macacae, identified using VITEK 2 COMPACT, MALDI-TOF MS, and 16S rRNA sequencing. The bacterium was susceptible to ceftriaxone and meropenem. Initial treatment with meropenem, followed by the addition of ceftriaxone after pathogen identification and susceptibility testing, led to significant improvement in inflammatory markers. Subsequent tricuspid valve surgery was successful.

Conclusions

: This case highlights the need to consider N. macacae in unexplained fever or infective endocarditis and underscores the value of advanced microbiological identification techniques.

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.