酸性磷脂体外激活血浆接触激活系统(Hageman因子系统)及β 2-糖蛋白I对该激活的抑制作用。

I Schousboe
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引用次数: 27

摘要

1. 带负电荷的磷脂促进血液凝固过程中接触活化系统的启动。2. 中性磷脂不能激活这个系统。3.2-糖蛋白I在生理浓度下可抑制其活化。4. 研究结果提出了一个问题,即β 2-糖蛋白I浓度低的人是否比β 2-糖蛋白I浓度正常的人更容易出现凝血缺陷,如弥散性血管内凝血。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In vitro activation of the contact activation system (Hageman factor system) in plasma by acidic phospholipids and the inhibitory effect of beta 2-glycoprotein I on this activation.

1. Negatively charged phospholipids promote initiation of the contact activation system in the blood coagulation. 2. Neutral phospholipids were unable to activate this system. 3. The activation is inhibited by beta 2-glycoprotein I at physiological concentrations. 4. The results raise the question whether people with low concentration of beta 2-glycoprotein I are more easily exposed to blood coagulation defects, such as disseminated intravascular coagulation, than those with normal concentration of beta 2-glycoprotein I.

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