肺动脉高压与原发性高血压模型中的肾素-血管紧张素系统。

IF 4.6 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Hypertension Research Pub Date : 2025-08-07 DOI:10.1038/s41440-025-02299-5

Yuki Nakayama, Satoru Eguchi

{"title":"肺动脉高压与原发性高血压模型中的肾素-血管紧张素系统。","authors":"Yuki Nakayama, Satoru Eguchi","doi":"10.1038/s41440-025-02299-5","DOIUrl":null,"url":null,"abstract":"Animal models of pulmonary arterial hypertension (PAH) demonstrate up-regulation of the renin angiotensin system. However, no clinical data are available to support the efficacy of angiotensin II inhibition in treatment for PAH. In this mini review, we will update the knowledge regarding regulation of the RAS system in PAH compared to primary hypertension in order to seek better treatments against PAH.","PeriodicalId":13029,"journal":{"name":"Hypertension Research","volume":"48 10","pages":"2522-2526"},"PeriodicalIF":4.6000,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41440-025-02299-5.pdf","citationCount":"0","resultStr":"{\"title\":\"The renin-angiotensin system in models of pulmonary arterial hypertension vs primary hypertension\",\"authors\":\"Yuki Nakayama, Satoru Eguchi\",\"doi\":\"10.1038/s41440-025-02299-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Animal models of pulmonary arterial hypertension (PAH) demonstrate up-regulation of the renin angiotensin system. However, no clinical data are available to support the efficacy of angiotensin II inhibition in treatment for PAH. In this mini review, we will update the knowledge regarding regulation of the RAS system in PAH compared to primary hypertension in order to seek better treatments against PAH.\",\"PeriodicalId\":13029,\"journal\":{\"name\":\"Hypertension Research\",\"volume\":\"48 10\",\"pages\":\"2522-2526\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-08-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.nature.comhttps://www.nature.com/articles/s41440-025-02299-5.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hypertension Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41440-025-02299-5\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hypertension Research","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41440-025-02299-5","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

摘要

肺动脉高压（PAH）动物模型显示肾素血管紧张素系统上调。然而，没有临床数据支持血管紧张素II抑制治疗PAH的有效性。在这篇小综述中，我们将更新RAS系统在PAH与原发性高血压中的调节知识，以寻求更好的治疗PAH的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The renin-angiotensin system in models of pulmonary arterial hypertension vs primary hypertension

查看原文本刊更多论文

The renin-angiotensin system in models of pulmonary arterial hypertension vs primary hypertension

Animal models of pulmonary arterial hypertension (PAH) demonstrate up-regulation of the renin angiotensin system. However, no clinical data are available to support the efficacy of angiotensin II inhibition in treatment for PAH. In this mini review, we will update the knowledge regarding regulation of the RAS system in PAH compared to primary hypertension in order to seek better treatments against PAH.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Hypertension Research 医学-外周血管病

CiteScore

7.40

自引率

16.70%

发文量

249

审稿时长

3-8 weeks

期刊介绍： Hypertension Research is the official publication of the Japanese Society of Hypertension. The journal publishes papers reporting original clinical and experimental research that contribute to the advancement of knowledge in the field of hypertension and related cardiovascular diseases. The journal publishes Review Articles, Articles, Correspondence and Comments.