替诺福韦二磷酸在干血斑浓度预测未来HIV抑制，但不能预测青少年HIV病毒病毒学失败。

IF 3.1 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2025-09-01 Epub Date: 2025-07-31 DOI:10.1097/QAD.0000000000004245

Sampson Antwi, Hongmei Yang, Anthony Enimil, Charles Martyn-Dickens, Albert Dompreh, Eugenia Sly-Moore, Dennis Bosomtwe, Aikins Kofi Amissah, Oluwayemisi Ojewale, Priscilla Asiedu, Augustina Frimpong Appiah, Theresah Opoku, Ama D Sarfo, Isaac Kusi-Amponsah, Lane R Bushman, Lucas Ellison, Peter L Anderson, Awewura Kwara

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引用次数: 0

摘要

我们研究了二磷酸替诺福韦（ttfv - dp）在干血斑（DBS）中的浓度是否能预测未来的病毒学结果。在52名感染艾滋病毒的青少年中，46%有病毒学抑制，44%有病毒学失败。DBS中ttfv - dp浓度与病毒学抑制有关，但与病毒学失败无关。26%病毒学失败的参与者在早期就诊时抗逆转录病毒依从性很高。在高依从性的情况下，病毒学失败可能表明存在HIV耐药性。

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Tenofovir diphosphate concentrations in dried blood spots predict future HIV suppression but not virologic failure in adolescents with HIV.

We investigated whether tenofovir diphosphate (TFV-DP) concentration in dried blood spot (DBS) predicted future virologic outcome. Of 52 adolescents with HIV, 46% had virologic suppression, and 44% had virologic failure. TFV-DP concentration in DBS was associated with virologic suppression but not virologic failure. Twenty-six percentage of participants with virologic failure had high levels of antiretroviral adherence at earlier visits. Virologic failure in the setting of high adherence may suggest the presence of HIV drug resistance.

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.