{"title":"染料木素在牙周炎防治中的研究进展","authors":"Yujun Lu, Yuye Liang, Zhiyuan Li, Wenxiu Li, Changjun Huang, Yajing Wang, Guangcheng Wang","doi":"10.1002/fsn3.70657","DOIUrl":null,"url":null,"abstract":"<p>Periodontitis is a chronic and progressive inflammatory disease of periodontal tissue whose characteristic pathological changes include the destruction of periodontal soft tissue and the absorption of alveolar bone. Genistein, an isoflavone compound derived from leguminous plants, has pharmacological effects such as anti-inflammatory, anti-oxidation, anti-bacteria, anti-osteoporosis, anti-tumor, and estrogen-like effects. In recent years, genistein has shown broad application potential in the prevention and treatment of periodontitis due to its wide range of biological activities. Therefore, this review presents the mechanism of action of genistein in the prevention and treatment of periodontitis and the different delivery strategies of genistein, aiming to provide ideas for the basic research and clinical application of genistein in taking precautions against and curing the effect of periodontitis.</p>","PeriodicalId":12418,"journal":{"name":"Food Science & Nutrition","volume":"13 8","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70657","citationCount":"0","resultStr":"{\"title\":\"Genistein in the Prevention and Treatment of Periodontitis: A Review\",\"authors\":\"Yujun Lu, Yuye Liang, Zhiyuan Li, Wenxiu Li, Changjun Huang, Yajing Wang, Guangcheng Wang\",\"doi\":\"10.1002/fsn3.70657\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Periodontitis is a chronic and progressive inflammatory disease of periodontal tissue whose characteristic pathological changes include the destruction of periodontal soft tissue and the absorption of alveolar bone. Genistein, an isoflavone compound derived from leguminous plants, has pharmacological effects such as anti-inflammatory, anti-oxidation, anti-bacteria, anti-osteoporosis, anti-tumor, and estrogen-like effects. In recent years, genistein has shown broad application potential in the prevention and treatment of periodontitis due to its wide range of biological activities. Therefore, this review presents the mechanism of action of genistein in the prevention and treatment of periodontitis and the different delivery strategies of genistein, aiming to provide ideas for the basic research and clinical application of genistein in taking precautions against and curing the effect of periodontitis.</p>\",\"PeriodicalId\":12418,\"journal\":{\"name\":\"Food Science & Nutrition\",\"volume\":\"13 8\",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-08-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.70657\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Science & Nutrition\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/fsn3.70657\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Science & Nutrition","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/fsn3.70657","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Genistein in the Prevention and Treatment of Periodontitis: A Review
Periodontitis is a chronic and progressive inflammatory disease of periodontal tissue whose characteristic pathological changes include the destruction of periodontal soft tissue and the absorption of alveolar bone. Genistein, an isoflavone compound derived from leguminous plants, has pharmacological effects such as anti-inflammatory, anti-oxidation, anti-bacteria, anti-osteoporosis, anti-tumor, and estrogen-like effects. In recent years, genistein has shown broad application potential in the prevention and treatment of periodontitis due to its wide range of biological activities. Therefore, this review presents the mechanism of action of genistein in the prevention and treatment of periodontitis and the different delivery strategies of genistein, aiming to provide ideas for the basic research and clinical application of genistein in taking precautions against and curing the effect of periodontitis.
期刊介绍：
Food Science & Nutrition is the peer-reviewed journal for rapid dissemination of research in all areas of food science and nutrition. The Journal will consider submissions of quality papers describing the results of fundamental and applied research related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.
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