Developing, fabrication and functionalization of soy bioactive peptides-nano particles therapeutic nano composites: A review

Nanoparticles (NPs) therapeutics has emerged as advanced systems for personalized therapeutics. However, they encounter several obstacles in attaining exact specificity and sensitivity for disease therapies. Therefore, the development of NPs with novel approaches is critically important to improve their therapeutic efficacy. One intellectual approach is assembling and compositing them with active biomaterials like smart disease targeting peptides. Bioactive peptides derived from soybeans, are reported to involve in several physiological functions like reducing chronic diseases such as cancer, cardiovascular disease (CVD) obesity, insulin-resistance/type II diabetes, immune disorders and inflammatory diseases. Therefore, the conjugation of soy bioactive peptides with nanoparticles is a promising strategy towards engineered therapeutic nano systems. However, these conjugates of soy peptides-nanoparticles composites (SPNCs) are highly under considered. Engineered nanoparticles with peptides, captured attention as innovative therapeutic platforms. Consequently, SPNCs engineered nanostructure, have the high potential for future therapeutics as their composite/hybrid features of therapeutic NPs and soy bioactive peptides, can not only enhance their therapeutic behaviors but also can resolve their challenges they face as an individual. In this review for the first time, multimodal SPNCs with acclaimed therapeutic abilities are discussed which set a foundational understanding for the future nanotherapeutics. The foundational details of soy peptides, NPs and their chemistries and corresponding interactions with disease modes are discussed. Finally, precise guidelines for accuracy techniques to engineer SPNCs with efficient therapeutic abilities are explored. This study established the groundwork for advancement of composite soy bioactive peptides with NPs to achieve therapeutic SPNCs with high target specific abilities.