涂有氧化石墨烯的锥形无芯光纤传感器，用于检测人体血红蛋白

IF 2.7 3区计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Optical Fiber Technology Pub Date : 2025-07-24 DOI:10.1016/j.yofte.2025.104351

Zhiheng Mu, Zhijiao Yang, Xingfan Han, Yanpeng Li, Xiaohong Sun

{"title":"涂有氧化石墨烯的锥形无芯光纤传感器，用于检测人体血红蛋白","authors":"Zhiheng Mu, Zhijiao Yang, Xingfan Han, Yanpeng Li, Xiaohong Sun","doi":"10.1016/j.yofte.2025.104351","DOIUrl":null,"url":null,"abstract":"<div><div>Abnormal hemoglobin (Hb) concentration is closely related to diseases such as anemia and kidney disease, and the development of highly sensitive and anti-interference Hb detection technology has important clinical implications. In this article, we develop a tapered no-core fiber (TNCF) sensor for detection of Hb concentration. By coating a graphene oxide (GO) thin film on the TNCF surface, a high sensitivity of 3.893 nm/(mg/ml) is obtained for the Hb solution with a concentration range of 0–1.0 mg/ml. Furthermore, through the sensing experiment of adding interfering substances to the Hb test solution, we have demonstrated the repeatability and anti-interference ability of the sensor. This study opens a new avenue for the application of TNCF in biochemical sensing and proves their potential for high-sensitivity and stable detection, demonstrating significant scientific and practical value.</div></div>","PeriodicalId":19663,"journal":{"name":"Optical Fiber Technology","volume":"94 ","pages":"Article 104351"},"PeriodicalIF":2.7000,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tapered No-Core fiber sensor coated with graphene oxide for the detection of human hemoglobin\",\"authors\":\"Zhiheng Mu, Zhijiao Yang, Xingfan Han, Yanpeng Li, Xiaohong Sun\",\"doi\":\"10.1016/j.yofte.2025.104351\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Abnormal hemoglobin (Hb) concentration is closely related to diseases such as anemia and kidney disease, and the development of highly sensitive and anti-interference Hb detection technology has important clinical implications. In this article, we develop a tapered no-core fiber (TNCF) sensor for detection of Hb concentration. By coating a graphene oxide (GO) thin film on the TNCF surface, a high sensitivity of 3.893 nm/(mg/ml) is obtained for the Hb solution with a concentration range of 0–1.0 mg/ml. Furthermore, through the sensing experiment of adding interfering substances to the Hb test solution, we have demonstrated the repeatability and anti-interference ability of the sensor. This study opens a new avenue for the application of TNCF in biochemical sensing and proves their potential for high-sensitivity and stable detection, demonstrating significant scientific and practical value.</div></div>\",\"PeriodicalId\":19663,\"journal\":{\"name\":\"Optical Fiber Technology\",\"volume\":\"94 \",\"pages\":\"Article 104351\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-07-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Optical Fiber Technology\",\"FirstCategoryId\":\"94\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1068520025002263\",\"RegionNum\":3,\"RegionCategory\":\"计算机科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Optical Fiber Technology","FirstCategoryId":"94","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1068520025002263","RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}

引用次数: 0

摘要

血红蛋白（Hb）浓度异常与贫血、肾病等疾病密切相关，开发高灵敏度、抗干扰的Hb检测技术具有重要的临床意义。在本文中，我们开发了一种锥形无芯光纤（TNCF）传感器用于检测Hb浓度。通过在TNCF表面涂覆氧化石墨烯（GO）薄膜，对浓度范围为0 ~ 1.0 mg/ml的Hb溶液获得了3.893 nm/(mg/ml)的高灵敏度。此外，通过在Hb测试溶液中加入干扰物质的传感实验，我们证明了传感器的重复性和抗干扰能力。本研究为TNCF在生化传感中的应用开辟了新的途径，证明了TNCF具有高灵敏度、稳定检测的潜力，具有重要的科学和实用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Tapered No-Core fiber sensor coated with graphene oxide for the detection of human hemoglobin

Abnormal hemoglobin (Hb) concentration is closely related to diseases such as anemia and kidney disease, and the development of highly sensitive and anti-interference Hb detection technology has important clinical implications. In this article, we develop a tapered no-core fiber (TNCF) sensor for detection of Hb concentration. By coating a graphene oxide (GO) thin film on the TNCF surface, a high sensitivity of 3.893 nm/(mg/ml) is obtained for the Hb solution with a concentration range of 0–1.0 mg/ml. Furthermore, through the sensing experiment of adding interfering substances to the Hb test solution, we have demonstrated the repeatability and anti-interference ability of the sensor. This study opens a new avenue for the application of TNCF in biochemical sensing and proves their potential for high-sensitivity and stable detection, demonstrating significant scientific and practical value.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Optical Fiber Technology 工程技术-电信学

CiteScore

4.80

自引率

11.10%

发文量

327

审稿时长

63 days

期刊介绍： Innovations in optical fiber technology are revolutionizing world communications. Newly developed fiber amplifiers allow for direct transmission of high-speed signals over transcontinental distances without the need for electronic regeneration. Optical fibers find new applications in data processing. The impact of fiber materials, devices, and systems on communications in the coming decades will create an abundance of primary literature and the need for up-to-date reviews. Optical Fiber Technology: Materials, Devices, and Systems is a new cutting-edge journal designed to fill a need in this rapidly evolving field for speedy publication of regular length papers. Both theoretical and experimental papers on fiber materials, devices, and system performance evaluation and measurements are eligible, with emphasis on practical applications.