封面特征：标签辅助液相寡核苷酸合成：趋同方法

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-07-23 DOI:10.1002/chem.202584002

Shinnosuke Akahane, Yuki Takahashi, Eimi Morikawa, Masae Sugai, Hideaki Umemoto, Takuya Onaka, Satoshi Ito, Naoto Taki, Yuya Yoshida, Yuto Toichi, Yoshikazu Kitano, Kazuhiro Chiba, Yohei Okada

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引用次数: 0

摘要

封面特征显示了我们的可溶性支持辅助液相寡核苷酸合成的示意图，使用一种新的标签，可以从市售的没食子酸甲酯制备而无需柱层析。在温和的还原条件下，可以选择性地切割保留保护基团的标签，以制备保护片段，这是实现收敛方法所必需的。更多信息可以在K. Chiba， Y. Okada及其同事的研究文章中找到（DOI: 10.1002/chem.202500616）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cover Feature: Tag-Assisted Liquid-Phase Oligonucleotide Synthesis: Toward a Convergent Approach

查看原文本刊更多论文

Cover Feature: Tag-Assisted Liquid-Phase Oligonucleotide Synthesis: Toward a Convergent Approach

The Cover Feature shows a schematic impression of our soluble support-assisted liquid-phase oligonucleotide synthesis using a novel tag that can be prepared from commercially available methyl gallate without column chromatography. Selective tag cleavages with protective groups remaining are made possible under mild reducing conditions to prepare protected fragments, which are necessary to realize a convergent approach. More information can be found in the Research Article by K. Chiba, Y. Okada and co-workers (DOI: 10.1002/chem.202500616).

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.