升级还是降级？2025年人乳头瘤病毒相关口咽癌的标准治疗方案是什么？

IF 1.4 4区医学 Q4 ONCOLOGY

Cancer Radiotherapie Pub Date : 2025-07-18 DOI:10.1016/j.canrad.2025.104674

Pierre Blanchard , Anne Aupérin , David Veyer , Hélène Péré , Michaël Chevrot , Laure Monard , Caroline Even , Haitham Mirghani

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引用次数: 0

摘要

几十年来，人乳头瘤病毒相关口咽癌的发病率一直在稳步上升。与酒精和烟草相关的口咽癌相比，它们的预后更好，因为它们对放疗和化疗更敏感，患者的合共病也更少。然而，一些肿瘤有很高的复发风险，因此可以考虑加强治疗。另一方面，对于预后良好的形式，已经考虑了许多治疗的降级策略。本文的目的是回顾2025年的护理标准，各种降低风险的策略，免疫治疗的潜在益处，以及人乳头瘤病毒对这些癌症监测和筛查的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Intensification or de-escalation? What is the standard treatment for human papillomavirus-related oropharyngeal cancers in 2025?

The incidence of human papillomavirus-related oropharyngeal cancers has been increasing steadily for several decades. They have a better prognosis than alcohol- and tobacco-related oropharyngeal cancers because they are more sensitive to radiotherapy and chemotherapy and patients have fewer comorbidities. However, some tumours have a high risk of recurrence, for which intensified therapy may be considered. On the other hand, for forms with a good prognosis, numerous therapeutic de-escalation strategies have been considered. The aim of this article is to review the standard of care in 2025, the various de-escalation strategies, the potential benefits of immunotherapy, and the impact of human papillomavirus on surveillance and screening of these cancers.

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来源期刊

Cancer Radiotherapie 医学-核医学

CiteScore

2.20

自引率

23.10%

发文量

129

审稿时长

63 days

期刊介绍： Cancer/radiothérapie se veut d''abord et avant tout un organe francophone de publication des travaux de recherche en radiothérapie. La revue a pour objectif de diffuser les informations majeures sur les travaux de recherche en cancérologie et tout ce qui touche de près ou de loin au traitement du cancer par les radiations : technologie, radiophysique, radiobiologie et radiothérapie clinique.